January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper discusses ethosomal drug delivery systems, highlighting their improved ability to enhance skin penetration and increase therapeutic effectiveness in treatments like acyclovir for herpes labialis and minoxidil for androgenic alopecia compared to standard formulations.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, a herbal shampoo using bael extract was formulated and found to have good cleansing efficiency and stable properties, suggesting it as a safe and eco-friendly alternative to synthetic shampoos with potential benefits for scalp health.
105 citations
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April 2017 in “International Journal of Nanomedicine” In this study, ethosomes were found to improve the skin penetration of a model lipophilic drug more effectively than liposomes or hydroethanolic solutions, suggesting a unique mechanism involving the breakdown of vesicles in the skin.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, a bael-based herbal shampoo formulation demonstrated effective cleansing, foaming ability, and stability, with antimicrobial properties that may benefit scalp health, positioning it as a promising natural alternative to synthetic shampoos.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.
2 citations
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June 1985 in “PubMed” This study observed that ethylenthiourea's lethality increases with dose accumulation and ethanol co-administration, while impaired liver function and various adverse effects were noted in long-term treated rats.
February 2018 in “Open MIND” This study found that both Glycyrrhiza glabra and Emblica officinalis extracts demonstrated significant antibacterial activity against Escherichia coli, with the highest effect seen in 100% crude extracts.
January 2000 in “Time to knit” This article describes the extraction and characterization method for wedelolactone from Eclipta alba but presents no new clinical results.
24 citations
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November 2018 in “International Journal of Molecular Sciences” This review discusses ethosomes as lipid carriers that enhance drug penetration into deep skin layers and underscores the need for advanced research on their pharmaceutical applications, but it reports no clinical outcomes.
November 2022 in “PLANT ARCHIVES” This study reported on 23 medicinal plant species used in Ben M'hidi, El-Tarf, Algeria, providing ethnobotanical insights into their traditional therapeutic applications.
February 2018 in “Zenodo (CERN European Organization for Nuclear Research)” This study reported that 100% crude extracts of Glycyrrhiza glabra and Emblica officinalis demonstrated strong antibacterial effects against Escherichia coli.
1 citations
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October 2018 in “InTech eBooks” This chapter reviews ethosomes for targeted drug delivery to the scalp in androgenetic alopecia and reports no clinical results; the authors emphasize reducing systemic side effects.
1 citations
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August 2017 in “Asian Journal of Pharmaceutical and Clinical Research” The 1% ethyl acetate fraction ethosomal gel from Nothopanax scutellarium leaves promotes hair growth but can mildly irritate the skin.
June 2026 in “International Journal of Plant & Soil Science” This narrative review examines the traditional uses and pharmacological properties of Eclipta alba, emphasizing its potential benefits like hepatoprotective and hair growth-promoting effects, but highlights the need for more clinical validation and a focus on preserving traditional knowledge.
April 2016 in “International Journal of Drug Delivery” This study found that finasteride ethosome formulations with specific ethanol and soya lecithin concentrations significantly enhanced transdermal drug delivery compared to a potential nanogel.
2 citations
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January 2024 in “Pakistan Journal of Life and Social Sciences (PJLSS)” This study examines the use of emulgel-based systems as drug delivery vehicles for hydrophobic medications, noting their potential benefits in dermatological applications due to properties like easy spreadability, non-greasy texture, and prolonged shelf life.
1 citations
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July 2023 in “International Journal of Pharmaceutical Sciences and Drug Research” This study developed an effective and reliable HPTLC method for the simultaneous measurement of linoleic acid and oleanolic acid in Eclipta alba.
September 2020 in “Pharmauho/Pharmauho : Jurnal Farmasi, Sains dan Kesehatan” This study concluded that hair tonic formulated with galangal rhizome and Aloe vera extract was stable according to the Indonesian National Standard, showing consistent organoleptic, pH, and viscosity characteristics after stability testing.
November 2003 in “Journal of Neurochemistry” This study suggests that the neurosteroid allopregnanolone may play a crucial role in how ethanol affects neurons related to alcohol addiction vulnerability.
June 2025 in “Universities Journal of Phytochemistry and Ayurvedic Heights” This study evaluated the wedelolactone content and antimicrobial activity of Eclipta alba and Wedelia chinensis extracts, finding a potential relationship between the concentration of wedelolactone and their in vitro antimicrobial effects against several pathogenic bacteria and yeast.
15 citations
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September 2018 in “Dermatologic therapy” In this study, the use of two emollients significantly reduced itching severity in individuals with xerotic eczema, starting 30 minutes post-application, and improved skin moisture and lipid content over 14 days, while demonstrating good tolerance with few adverse events.
14 citations
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July 2007 in “Therapy” This review discusses ethosomes as potential carriers for delivering drugs into deeper skin layers and provides no new clinical results, suggesting a need for further studies on their efficiency in dermal therapies.
In this laboratory study, the methanolic extract of Eclipta alba demonstrated significant anthelmintic activity against earthworms (Pheretima posthuma), causing paralysis and death at doses of 50-100 mg/ml, with stronger effects observed at higher concentrations compared to the standard treatment, albendazole.
10 citations
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January 2009 in “Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico)” This study found that Eclipta alba extracts exhibit significant antimicrobial activity against various human pathogens, including antibiotic-resistant strains, suggesting potential use in treating infectious diseases.
10 citations
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January 2014 in “Chemical and Pharmaceutical Bulletin” This study found that hair follicle-plugging reduced skin permeation of certain model drugs, with effects varying based on EtOH pretreatment and the drug being evaluated.
February 2024 in “Jurnal Kesehatan Yamasi Makassar” This study in South Sulawesi Province developed a shampoo using ethanol extract from Pondoh salak fruit peel, which met physical stability tests and demonstrated strong inhibitory effects against Staphylococcus epidermidis and Candida albicans, with formulations ranging from 10% to 20% concentrations.
September 2020 in “Eureka: Health Sciences” In this study, the researchers developed an optimal emulgel formulation for treating androgenic alopecia, determining that a base with 0.3% Carbomer Ultraz 10, 0.1% potassium sorbate, and 0.2% triethanolamine offered the best properties for drug release, application compliance, safety, and stability.
In this study, thalamic GABAA receptor α4 subunit levels were regulated after acute and chronic ethanol exposure, with temporal expression changes affected by phosphorylation state and neuroactive steroids.
July 2026 in “Journal of the Kenya National Commission for UNESCO” In this study, commercial synthetic braiding hair samples from Kenya were analyzed, revealing that while no Ammonium Thioglycolate was detected, significant formaldehyde contamination was present, with varying concentrations throughout the hair strands, potentially impacting consumer safety.
11 citations
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January 2020 in “Micro and Nanosystems” This study found that transethosomal gel loaded with propranolol hydrochloride prolonged drug release and increased peak plasma concentration compared to an oral tablet, suggesting a promising alternative for delivery.