Estimation of Wedelolactone in Eclipta Alba and Wedelia Chinensis and Comparative Antimicrobial Activity Against Pathogenic Bacteria

The study found that Eclipta alba contains a higher wedelolactone content (0.040% w/w) than Wedelia chinensis (0.031% w/w), making it a more efficient source for extraction. However, Wedelia chinensis demonstrated superior antimicrobial activity, possibly due to the synergistic effects of other phytochemicals. Both plants were effective against pathogens such as Staphylococcus aureus, E. coli, Pseudomonas aeruginosa, and Candida albicans, with methanol identified as the most effective extraction solvent. The research suggests the potential of these plants in developing antimicrobial agents.