Antimicrobial Activities of Ethanol Extract and Coumestans from Eclipta Alba (L.) Hassk (Asteraceae)

    January 2009 in “ Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) ”
    Vanessa A. Lenza, Lucas Junqueira de Freitas Morel, Juliana da Silva Coppede, Vanessa C. Fernandes, Nilce Maria Martinez-Rossi, Suzelei de Castro França, René Oliveira Beleboni, Paulo Sérgio Pereira, Ana Lúcia Fachin
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    Studysummary This study found that Eclipta alba extracts exhibit significant antimicrobial activity against various human pathogens, including antibiotic-resistant strains, suggesting potential use in treating infectious diseases.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study investigated the antimicrobial activities of ethanol extract and coumestans from Eclipta alba against various human pathogenic bacteria and fungi. The compounds demethylwedelolactone/wedelolactone (DWL/WL) and wedelolactone (WL) effectively inhibited strains of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli, as well as antibiotic-resistant Enterococcus spp and S. aureus, with minimal inhibitory concentrations ranging from 75 to 250 µg/mL. The ethanol extract was more effective than purified fractions against Trichophyton rubrum, indicating a synergistic effect with other compounds in the extract. The findings suggested that E. alba had significant antimicrobial activity, including against multi-drug resistant microorganisms, which could be important for treating infectious diseases.
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