Antimicrobial Activities of Ethanol Extract and Coumestans from Eclipta Alba (L.) Hassk (Asteraceae)

    January 2009 in “ Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) ”
    Vanessa A. Lenza, Lucas Junqueira de Freitas Morel, Juliana da Silva Coppede, Vanessa C. Fernandes, Nilce Maria Martinez-Rossi, Suzelei de Castro França, René Oliveira Beleboni, Paulo Sérgio Pereira, Ana Lúcia Fachin
    TLDR Eclipta alba extract effectively kills various harmful bacteria and fungi, including drug-resistant ones.
    The study investigated the antimicrobial activities of ethanol extract and coumestans from Eclipta alba against various human pathogenic bacteria and fungi. The compounds demethylwedelolactone/wedelolactone (DWL/WL) and wedelolactone (WL) effectively inhibited strains of Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli, as well as antibiotic-resistant Enterococcus spp and S. aureus, with minimal inhibitory concentrations ranging from 75 to 250 µg/mL. The ethanol extract was more effective than purified fractions against Trichophyton rubrum, indicating a synergistic effect with other compounds in the extract. The findings suggested that E. alba had significant antimicrobial activity, including against multi-drug resistant microorganisms, which could be important for treating infectious diseases.
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