5 citations
,
May 2020 in “Dermatologic Therapy” This letter reports no new findings and discusses potential concerns regarding 5-alpha reductase inhibitors on lung function, suggesting a reason for discontinuation during the COVID-19 pandemic.
4 citations
,
September 2024 in “Frontiers in Endocrinology” This study found that serum steroid profiling, particularly 11-deoxycortisol, can effectively differentiate between ACC and ACA, while considering sex differences and functional status for other steroids is important.
2 citations
,
June 2023 in “Journal of cell science” In this study, researchers found that specific mutations in iRhom2 in mice lead to skin and hair abnormalities which depend on the presence of the protein ADAM17, suggesting a complex role for iRhom2 in tissue development and potential implications for treating tylosis with oesophageal cancer.
1 citations
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March 2025 in “Medical Molecular Morphology” This review discusses how androgens, commonly known for male reproductive roles, also influence the physiology and pathology of the human endometrium, though their exact roles in this tissue remain controversial and not fully understood.
January 2026 in “Frontiers in Cellular Neuroscience” This study discusses the complex roles and effects of brain-synthesized sex neurosteroids, highlighting sex differences in their concentrations and their varied impacts on synaptic plasticity, cognitive behavior, and aging-related cognitive decline.
This study utilized a mouse model of traumatic brain injury to reveal that acute neurotrauma triggers widespread lipid metabolism reprogramming and storage lipid accumulation in microglial and monocyte populations, leading to lysosomal dysfunction, inhibited autophagy, and exacerbated inflammation through a pathological feedback loop.
This article provides tables summarizing various medical conditions and symptoms related to COVID-19, sepsis, and cardiovascular issues, but it does not report new research findings.
January 2012 in “Durham e-Theses (Durham University)” This study found that knock-down of keratin 15 in various cell lines affected cell spreading, morphology, migration, differentiation, and proliferation, suggesting its role in maintaining the stem cell nature of keratinocytes.
January 2009 in “Side effects of drugs annual” This study observed no teratogenic effects of oral decongestants and surprisingly favorable neonatal outcomes in Swedish women who used them during pregnancy.
101 citations
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August 2010 in “PLoS ONE” In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.
65 citations
,
May 2017 in “Advances in wound care” This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.
28 citations
,
December 2018 in “Plant, cell & environment/Plant, cell and environment” This study found that the PLC2 gene plays a critical role in auxin-mediated root development in Arabidopsis, influencing root growth and PIN2 distribution.
13 citations
,
March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
8 citations
,
April 2019 in “Dermatologic Therapy” This study found that applying topical tretinoin can influence follicular sulfotransferase expression, enabling 43% of predicted nonresponders to minoxidil to respond positively in the context of androgenetic alopecia.
January 2026 in “Nano-Micro Letters” This review discusses the principles, materials, and applications of melt electrowriting-based 4D printing for creating biomimetic scaffolds, but reports no new clinical results; it highlights recent advancements and remaining challenges in the field.
April 2024 in “BMB Reports” This study used Cisd2 knockout mice models and found that these mice display premature aging characteristics and an increase in dysfunctional neutrophils, suggesting Cisd2's role in calcium homeostasis and neutrophil function via interactions with Calnexin and SERCA.
March 2024 in “Frontiers in genetics” This review discusses the insights gained from single-cell RNA sequencing of fibroblasts in various cancers and wound healing, highlighting differences in gene expression and novel interactions.
January 2015 in “Springer eBooks” Hair health is influenced by genetics, aging, and environmental factors, with proper care needed to maintain it.
April 2017 in “Journal of Investigative Dermatology” Psoriasis patients experience moderate functional impairment related to disease severity and less satisfaction.
47 citations
,
June 2009 in “Journal of Biological Chemistry” This study found that finasteride competitively inhibits the enzyme AKR1D1 with low micromolar affinity but does not act as a mechanism-based inactivator.
269 citations
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May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
71 citations
,
November 2012 in “Expert Opinion on Drug Safety” This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.
57 citations
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July 2016 in “The Journal of Sexual Medicine” This study concluded that 5α-reductase inhibitors were linked to increased sexual dysfunction in men with benign prostatic hyperplasia, but not in men with androgenetic alopecia.
54 citations
,
May 2017 in “Biomedicine & Pharmacotherapy” This review discusses the nutrient profile and potential health benefits of pumpkin and watermelon seeds, concluding they are underutilized and could be developed into various nutraceuticals.
36 citations
,
September 2009 in “Journal of Cellular and Molecular Medicine” This review addresses the role of skin-resident adult stem/progenitor cells in skin homeostasis, disease, and cancer development, and reports no new research results.
30 citations
,
June 1988 in “Journal of Steroid Biochemistry” This study found that combining Flutamide and an LHRH agonist in adult male rats effectively inhibited prostatic growth and reduced androgen-sensitive prostatic activity markers to levels similar to castrated rats.
25 citations
,
February 2012 in “The Journal of Sexual Medicine” In this study, oral finasteride treatment for four weeks reduced the weight of the corpus cavernosum in rats but did not significantly affect erectile function.
23 citations
,
June 2017 in “Rejuvenation Research” In this study, minoxidil treatment in aged mice increased elastin expression and improved aortic structure and function, suggesting its potential for arterial remodeling in aging.
18 citations
,
July 2021 in “Molecular Medicine Reports” This review summarizes existing knowledge of how the WNT signaling pathway affects mesenchymal stem cells under various conditions, highlighting challenges and mechanisms for clinical applications.
10 citations
,
August 2019 in “The World Journal of Men's Health” This study found that administering a kimchi and cheonggukjang probiotic product promoted hair growth and increased hair thickness in individuals with patterned hair loss without causing adverse effects.