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This study found that C8/144B antibody exclusively binds to the hair follicle bulge and not the epidermal stratum basale, with cytokeratin 19 serving as a key marker of certain basal keratinocytes that decrease with age.

In this study, engineered skin substitutes containing murine dermal papilla cells developed hair follicle-like structures when grafted onto mice, suggesting a model for generating chimeric hair.

This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.

This review highlights the need for improved methods in cosmetic safety assessment, emphasizing the potential of engineered skin tissue for more effective detection and toxicological evaluation of cosmetic products, compared to traditional methods.

This study found that basal keratinocytes in engineered skin substitutes showed a proliferative phenotype and potential for long-term replication, which may enhance wound healing stability.

This study found that engineered skin substitutes made with skin-derived precursors and epidermal stem cells can regenerate hair follicles after grafting into nude mice.

This study demonstrates that trichogenic dermal papilla cells are crucial for hair regeneration in engineered skin substitutes, with adult murine cells showing higher activity than adult human cells.

This review discusses the modern approach of skin tissue engineering for chronic wound treatment, focusing on bioengineered artificial skin substitutes and assessing innovations in biomaterials and cell use; it reports no new clinical results.

This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.

This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of Lactobacillus reuteri and Lactococcus cremoris have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.

In this study, treatment with cell-derived nanovesicles from hair follicle mesenchymal stem cells improved photoaging signs in UVB-exposed mice and human dermal fibroblasts by reducing oxidative stress, enhancing cell proliferation, and promoting extracellular matrix production.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

Hair follicles help guide nerve growth, improving touch recovery in skin grafts.

This study found that tissue-engineered skin using mouse fibroblasts successfully supported hair growth after grafting, but similar success was not observed using human fibroblast-derived tissue.

This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.

In this study, epidermal stem cells were found to enhance blood vessel formation and support successful one-step transplantation of tissue-engineered skin in a rat model.

This study found that an enzymatic digestion method for isolating hair follicle stem cells from scalp specimens yielded 5.3 times more epithelial cells than explant cultures, while supporting comparable cell functionality, offering a promising technique for tissue engineering and regenerative medicine.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.

Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.

This study constructed a 3D-printed scaffold using sodium alginate, gelatin, and alginate lyase hydrogel, which supports hair follicle regeneration in artificial skin, suggesting a promising strategy for tissue-engineered skin with functional appendages.

This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.

This study found that incorporating dermal papillae cells and keratinocytes into dermal substitutes promoted better wound healing, reduced contraction, and enabled appendage formation in tissue-engineered skin on mice.

This study found that hair follicle stem cells can proliferate and differentiate into keratinocytes on chitosan skin-engineered templates, suggesting potential applications in regenerative medicine.

In this study, researchers demonstrated that fibroblasts derived from human embryonic stem cells can be used to create tissue-engineered dermal substitutes, effectively repairing mouse skin wounds within 20 days, highlighting a promising method for clinical applications in skin repair.

In an animal study with a skin defect model, this research reported that curcumin-loaded hydrogels made from recombinant humanized collagen and an eco-friendly crosslinker enhanced wound repair by promoting angiogenesis, granulation tissue formation, and hair follicle neogenesis, while providing antioxidant benefits.

This review highlights the potential of genetically or metabolically engineered live biotherapeutic products (eLBPs) for skin repair and disease treatment but emphasizes that translating these innovations into practical clinical applications remains challenging, requiring further research and development.

Early-stage skin substitutes improve wound healing and skin structure.

This study found that combining LED yellow light with an engineered strain expressing CXCL12 improved wound healing and reduced inflammation in a mouse model of scald wounds.

This study reports that tissue-engineered skin using ES cell-derived epidermal stem cells and collagen sponge successfully healed full thickness skin defects in mice, forming epidermis and structures resembling glands and hair follicles.