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In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.

This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.

This study demonstrated that engineered exosomes loaded with growth factors, EGF and FGF, could successfully repair the hair follicle microenvironment in an androgenetic alopecia mouse model, enhancing hair growth without causing adverse immune reactions or toxicity.

This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.

This article reviews microneedle technology as a transdermal drug delivery platform without presenting new clinical results, emphasizing its engineered microstructure arrays for enhanced penetration.

This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.

This study found that a bioorthogonal microneedle patch delivering AAV-aFGF effectively improved hair follicle regeneration and sustained hair growth in murine alopecia models compared to other methods.

This review highlights the potential of bioengineered dermal scaffolds in tissue engineering to enhance wound healing by mimicking the dermal structure and supporting cellular processes, while also discussing recent advancements and challenges in scaffold technology.

This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.

In this study, re-activating SOX9 in adult epidermal stem cells led to a fate switch towards hair follicle stem cell identity, with altered chromatin dynamics and oncogenic activation, contributing insights into developmental processes and cancer pathways.

This study describes the use of a genetically engineered mouse model, mTurquoise2-Col4a1, to fluorescently label collagen IV and observe basement membrane dynamics during skin development, revealing its stability and pliability during rapid growth phases.

This article proposes several potential approaches for scar prevention and therapy, including anti-transforming growth factor-β strategies and tissue-engineered skin, but reports no new clinical results.

This review highlights how organoid technology is transforming precision medicine by summarizing its development and applications in modeling diseases, testing drug efficacy, and tailoring patient-specific treatments, despite current challenges in standardization and ethical considerations.

This study reviews advancements in hair follicle regeneration, discussing the benefits and limitations of methods such as organ germ assembling, stem cell induction, and bioprinting, while highlighting the challenges of replicating embryonic signals and finding suitable cell sources for clinical applications.

This systematic review reports that bioprinting technology holds significant potential for improving patient quality of life by enabling personalized medical treatments, reducing organ transplant rejection risks, and accelerating skin tissue regeneration, although many advancements are still at the research stage.

This study established methods to isolate, culture, and expand rat hair follicle stem cells, which showed good proliferation and could serve as a cell source for tissue-engineered applications.

This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.

This study demonstrated that safflower seeds can be engineered to express oleosin-FGF10, which showed a dose-dependent effect on cellular proliferation, potentially facilitating scalable protein production.

In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.

This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.

This study found that dermal papilla-like tissues derived from canine adipose stem cells promoted new hair follicle formation and increased vascularization in athymic nude mice.

This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.

In this study using rabbits, HA2 hydrogels made from cross-linked hyaluronic acid and polysaccharide promoted wound healing better than other treatments, reducing inflammation and scar formation.

This review found that 3D bioprinting significantly advances skin tissue engineering by enabling the creation of complex, patient-specific skin structures, though technological and regulatory challenges persist, particularly in areas like scalability and physiological mimicry.

This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.

This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.

This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.

This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.

This study demonstrated that intraoperative bioprinting using a bioink with human adipose-derived extracellular matrix and stem cells achieved successful reconstruction of full-thickness craniomaxillofacial skin defects in rats, promoting wound closure, adipogenesis, and hair follicle-like structure formation within two weeks.

In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.