1 citations
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January 1993 in “Skin Pharmacology and Physiology” This study found that an extracellular calcium binding site gradient exists in mouse vibrissa and human scalp follicles, but is not significantly affected by hair growth-altering drugs or epidermal growth factor.
September 2023 in “Skin appendage disorders” This pilot study detailed the use of Hair-to-Hair-matching technology™ in a clinical trial to assess botulinum toxin's efficacy in treating male androgenetic alopecia, providing a precise method for evaluating hair count and thickness changes over time.
45 citations
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December 2007 in “The FASEB journal” This study demonstrated that hair follicle bulge stem cells can form epidermis in a tissue-engineered skin model, highlighting the significance of K5/K17 filaments in slow-cycling stem cell subsets.
January 2022 in “Stem cell biology and regenerative medicine” This review discusses advances in using tissue engineering to improve the inductivity of dermal papilla cells for hair follicle restoration and reports no new clinical results.
August 2018 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the history and evolution of techniques for detecting bioelectromagnetic emissions from living tissues, exploring potential medical applications, but does not present new experimental results.
14 citations
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July 1983 in “Acta Dermato Venereologica” This study describes a method for serially cultivating adult human hair follicle keratinocytes using a specific growth substrate and cryogenic storage, enabling subculture and immunofluorescence studies.
April 2026 in “Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy” 8 citations
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March 2009 in “Differentiation” The study demonstrated that bulge stem cells from rat vibrissa follicles respond to adult dermal papilla signals, inducing hair bulb formation and regenerating hair structures in vivo.
January 2013 in “The Pan African medical journal” This report describes two cases of monilethrix in Afghan siblings, detailing the hair disorder's clinical presentation and potential influences on hair growth, such as hormonal changes and iron supplementation.
12 citations
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August 2018 in “Journal of Dermatological Science” This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.
36 citations
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August 2018 in “Dermatologic Clinics” This article reviews various hair abnormalities observable through trichoscopy in conditions like monilethrix, trichorrhexis nodosa, and ectodermal dysplasias, with no new clinical findings reported.
6 citations
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November 2001 in “Der Hautarzt” This article reviews new developments in hypertrichosis treatments and reports no new clinical results; permanent depilation by photothermolysis and eflornithine cream are highlighted as promising options.
8 citations
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January 2014 in “PubMed” This study demonstrated that dermal papilla cells were more efficiently reprogrammed into induced pluripotent stem cells than dermal fibroblasts, suggesting their potential as a source for iPS cells.
August 2023 in “Stem cell reviews and reports”
149 citations
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July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
13 citations
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March 2012 in “The Journal of Dermatology” This study reports that transplanted mouse hair follicles restored piloerection ability and connected properly with host tissues, suggesting potential for advanced hair restoration therapies.
27 citations
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April 1978 in “Journal of Forensic Sciences” This study explored the potential of using isoenzyme detection after electrophoresis to characterize human hair, though no new clinical results are reported.
September 2016 in “Journal of Dermatological Science” This study found that extracellular factors from a specific developmental stage can promote hair follicle neogenesis in adult skin by facilitating interactions between fibroblasts and keratinocytes.
April 2000 in “Chinese Journal of Dermatology” This study found that epidermal growth factor may stimulate the growth of hair follicle epithelium and potentially accelerate the transition from anagen to catagen phase in cultured human hair follicles.
September 2016 in “Journal of The American Academy of Dermatology” This case study identified the condition as Monilethrix in a 17-year-old female, characterized by a beaded hair appearance and linked to a genetic cause.
98 citations
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June 2008 in “Human mutation” This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
46 citations
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November 2007 in “Gene Expression Patterns” This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.
1 citations
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May 2021 in “Dermatology practical & conceptual” This study found that iontophoresis combined with growth factors improved hair density and reduced hair loss in patients with androgenetic alopecia and telogen effluvium, with no serious side effects reported.
47 citations
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August 2012 in “Cell Cycle” This study found that multipotent, nestin-expressing stem cells from the upper part of hair follicles can proliferate significantly and differentiate into various cell types, showing potential for nerve and spinal cord repair.
43 citations
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August 2008 in “Regenerative Medicine” In this study, murine follicular cell aggregates developed into hair-like structures in culture, which upon implantation into mice skin matured into complete hair follicles, suggesting potential for treating hair loss.
In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.
40 citations
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June 2013 in “Biomaterials” This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.
249 citations
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May 2003 in “Developmental Biology” Ectodysplasin-A1 is crucial for developing hair, teeth, and glands.
June 2025 in “International Journal of Molecular Sciences” In this study, researchers used spatial transcriptomics to identify increased expression of genes linked to extracellular matrix organization and epithelial–mesenchymal transition in the progenitor cell regions of hair follicles in androgenetic alopecia patients, suggesting a possible role in progenitor cell loss and fibrogenic microenvironment development.
179 citations
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April 2012 in “Nature Communications” This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.