January 2026 in “International Journal of Biological Macromolecules” This study found that different polypeptides, including KP peptide and hydrolyzed keratin, can improve the mechanical properties of damaged hair under varying conditions, with reduction environments and cysteine content influencing their effectiveness.
July 2025 in “Cosmoderma” In this study, a 90-day course of a plant-based supplement significantly improved hair density, skin hydration, and nail growth among participants with dermatological concerns, while also reducing hair fall and pigmentation, without adverse effects.
This review concluded that the efficacy of cosmeceutical hair serums for addressing hair loss lies in their use of bioactive peptides and plant compounds, like flavonoids and sterols, that target eight key contributing factors identified in hair loss conditions.
328 citations
,
November 2020 in “Nature Materials” This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.
96 citations
,
December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
10 citations
,
February 2014 in “Fitoterapia” This study found that Pomiferin may effectively stimulate extracellular matrix protein expression in skin and scalp models, with results comparable to retinol, suggesting potential as a topical treatment ingredient.
8 citations
,
July 2022 in “International Journal of Molecular Sciences” This review reports no new results but highlights the secretory function of keratinocytes, focusing on how various secretions, notably growth factors, impact stem cell differentiation into keratinocytes.
1 citations
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November 2025 in “Molecules” This review highlights the potential of ellagic acid for treating various skin conditions due to its antioxidant, anti-inflammatory, and depigmenting properties, but notes that novel formulations are needed to overcome its poor solubility and skin permeability to enhance clinical efficacy.
1 citations
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January 2024 in “Microorganisms” This study suggests that the synthetic peptide SPIKENET (SPK) may protect against long-term skin alterations in mice following coronavirus infection, offering potential therapeutic intervention for similar effects in humans post-COVID-19.
1 citations
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April 2023 in “Scientific Reports” This study reported that newly developed RADA16-I peptide hybrids, with active motifs like GHK and KGHK, demonstrated improved wound healing in a mouse skin injury model without cytotoxicity, suggesting they might be effective scaffolds for tissue engineering and regeneration.
October 2024 in “Frontiers in Veterinary Science” This study identified key proteins, FKBP10 and FBN2, that promote the growth cycle of secondary hair follicles in cashmere goats, with higher expression in the anagen phase, offering insights into mechanisms potentially enhancing cashmere yield and quality.
21 citations
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November 2023 in “International Journal of Molecular Sciences” This ex vivo study reported that melatonin significantly improved certain aging biomarkers in aged human skin, including reduced mTORC1 activity, increased fibrillin-1, and enhanced collagen and elastic fiber organization, though other key biomarkers remained unchanged.
2 citations
,
March 2014 in “The Egyptian Journal of Histology” The study concluded that local administration of in-vitro-expanded bone marrow-derived mesenchymal stem cells accelerates and promotes healing in full-thickness excisional wounds in adult male albino rats.
54 citations
,
January 2023 in “Signal Transduction and Targeted Therapy” This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.
9 citations
,
March 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This symposium reviewed various advances in understanding and potentially reversing skin aging, with no new experimental results reported.
5 citations
,
December 2023 in “Materials” This review paper highlights the development and application of organic and biogenic nanocarriers for delivering bioactives, focusing on eco-friendly and sustainable nanotechnology strategies while addressing challenges like toxicity and paving the way for future innovations in green solution approaches.
February 2024 in “Skin health and disease” This source reviews popular cosmeceutical ingredients for skin care, noting that while they are popular among consumers for anti-aging benefits, many lack robust clinical evidence for their efficacy and safety, as they are not regulated by the FDA.
50 citations
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February 2022 in “Nanomaterials” This review discusses the mechanisms involved in wound healing and explores the potential of nanomaterials as a promising approach to managing chronic wounds, but reports no new clinical findings.
August 2026 in “Dermatology and Therapy” In this study, patient-reported outcomes indicated that greater weight loss with GLP-1RA treatments was associated with increased reports of adverse cosmetic effects such as skin laxity, facial volume loss, and hair shedding, despite improvements in some preexisting inflammatory skin conditions.
February 2025 in “International Journal of Cosmetic Science” This research studied European human hair, finding that cysteic acid and protein carbonylation increased with both chemical and photochemical oxidation. Protein carbonylation was highlighted as a more sensitive marker for photochemical oxidation, providing better in situ visualization of hair damage than cysteic acid.
23 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review discusses the role of defensin peptides in stem cell activation for potential skin rejuvenation therapies and reports no new clinical findings, emphasizing the need for further studies.
1 citations
,
April 2017 in “Journal of Investigative Dermatology” This study evaluated the effects of topical glucocorticoids on human skin using non-invasive imaging methods and observed changes such as alterations in skin layer thickness, keratinocyte size, and collagen and elastin signal intensity.
January 2015 in “Elsevier eBooks” This chapter reviews the use of liposomes and cyclodextrins to improve the delivery and effectiveness of the peptide angiotensin-(1-7) in various therapeutic applications and reports no new experimental results.
This study in diabetic db/db mice found that treatment with the antihypertensive agents minoxidil or nebivolol stimulated elastogenesis and inhibited elastolysis, leading to restored elastic fibers, reduced aortic stiffening, and normalized blood pressure.
1 citations
,
January 2023 in “Journal of pharmaceutical and biological sciences” This review examines ethosomal structures and their mechanisms as skin delivery systems, outlining preparation methods and applications but presents no new experimental findings.
September 2025 in “Clinics and Practice” This study found that six-month supplementation with fish-derived collagen peptides, calcium, and vitamin D3 improved skin hydration and elasticity and reduced hair loss in menopausal women, with collagen playing a dominant role in enhancing skin elasticity.
7 citations
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September 2020 in “International Journal of Cosmetic Science” This study investigated the effects of wool-derived hydrolysed keratin peptides on relaxed textured hair and found that mid- and high-molecular weight peptides improved mechanical strength and reduced breakage in different humidity conditions.
This review highlights concerns about dermatological side effects linked to rapid weight loss from glucagon-like peptide-1 receptor agonists used for type 2 diabetes and obesity treatment, such as skin laxity, decreased collagen, and hair loss, emphasizing the importance of managing these while retaining metabolic benefits.
12 citations
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April 2023 in “Frontiers in Materials” This review discusses the biofunctionalization of hydrogel scaffolds for vascular tissue regeneration and reports promising results from in vivo studies, such as improved angiogenesis and healing in pressure ulcers when using specific peptides.
6 citations
,
July 2025 in “Pharmaceuticals” This review highlights the promising biomedical applications of marine-derived polysaccharides, proteins, and peptides, particularly in drug delivery and wound healing. It discusses their potential as biomaterials in creating nanocarriers, hydrogels, and more, alongside fabrication strategies, regulatory challenges, and sustainability considerations.