Carbonylation of Hair Proteins: A Robust Biomarker of Molecular and Structural Oxidative Damage in Hair Fibers

    February 2025 in “ International Journal of Cosmetic Science ”
    Camille Grosjacques, Sabine Babiel, Jing Hodes, Anaïs Bobier, Andrea Cavagnino, Martín A. Baraibar
    Image of study
    TLDR Protein carbonylation is a sensitive marker for oxidative damage in hair, especially from light exposure.
    The study explores oxidative damage in hair proteins, emphasizing protein carbonylation as a sensitive biomarker for assessing molecular and structural damage. It reveals that carbonylation affects a significant portion of hair's amino acids (33%) and correlates with increased fragility and reduced strength. The research shows that chemical treatments like bleaching cause more damage than UV exposure, with protein carbonylation increasing more rapidly in blonde hair, highlighting melanin's protective role. The study finds an inverse relationship between carbonylation levels and denaturation temperature, indicating structural weakening. Overall, protein carbonylation is a more reliable indicator of oxidative damage than cysteic acid, providing insights into hair integrity and the effects of oxidative treatments.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 715 results

      community Shampoo + Protein shake causing hair shedding?

      in Ketoconazole 6 months ago
      The user started using ketoconazole shampoo and whey protein shakes and noticed increased hair shedding, seeking advice on whether these could be the cause. Another user shared their experience with hair loss after starting protein shakes and mentioned using finasteride, which eventually improved their hair condition.

      community Vegan Protein Powder Make Loss Worse?

      in Female  2 upvotes 1 year ago
      A user is experiencing genetic hair loss and is using spironolactone and minoxidil without success. They are considering switching to vegan protein powder due to digestive issues and are concerned if it will worsen hair loss.

      community Can Whey Protein isolate make your AGA worse?

      in Product  10 upvotes 2 years ago
      Whey protein isolate may worsen androgenetic alopecia (AGA) due to its potential to increase DHT levels, but finasteride use has helped maintain hair. Some users suggest avoiding protein supplements due to possible contaminants and additives that could affect hair health.

      community Whey protein and hair loss

       7 upvotes 8 years ago
      Whey protein does not cause hair loss; concerns are likely unfounded. The user is on finasteride and minoxidil but sees no improvement, so they are phasing out these treatments while continuing to work out and use whey protein.

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  81 upvotes 1 year ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

      community Creatine / Whey Protein / Finasteride Hair Loss?

      in Finasteride/Dutasteride  6 upvotes 1 year ago
      A 37-year-old with a receding hairline started using finasteride and plans to add minoxidil, concerned that creatine and whey protein might accelerate hair loss. Another user suggests these supplements likely don't increase testosterone or cause hair loss, advising to monitor personal experience.

    Similar Research

    5 / 1000+ results