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270-300 / 1000+ resultsresearch Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity
This study found that epidermolysis bullosa simplex keratinocytes had impaired mitochondrial activity and more dispersed mitochondrial distribution compared to normal human keratinocytes.
research Mutations in KLHL24 Add to the Molecular Heterogeneity of Epidermolysis Bullosa Simplex
This study identified KLHL24 as a new gene linked to a subtype of epidermolysis bullosa simplex, highlighting its role in unresolved cases by involving a degradation-resistant truncated protein impacting keratin turnover.
research Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients
This study observed that the ethyl acetate extract of Equisetum debile showed high activity against 5α-reductase and lipid peroxidation with no cytotoxicity on dermal papilla cells.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
This study found that cathepsin L deficiency in mice led to significant abnormalities in hair follicle development and cycling, including disrupted hair shaft outgrowth and premature hair growth phase entry.
research Eco-Friendly Extraction and Formulation of Black Sea Shark Liver Oil-Based Emulgel for Anti-Inflammatory and Healing Dermatocosmetic Applications
This study explored Black Sea shark liver oil-based emulgels, finding that the addition of borage oil (Gel 2) enhanced the anti-inflammatory and wound healing properties compared to shark liver oil alone (Gel 1) and a reference diclofenac gel, suggesting promising eco-friendly applications in dermatocosmetics.
research Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing
In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.
research 973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin
This study found that DPP4 is significantly involved in matrix deposition and fibrosis in human skin fibroblasts, although the exact functions of DPP4 remain unclear.
research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin
This study found that mice lacking sPLA2-IIE had distinct skin abnormalities, particularly affecting hair follicles, highlighting the differing roles of sPLA2 isoforms in mouse skin.
research Protease activity, localization and inhibition in the human hair follicle
This study found that a combination of Trichogen and climbazole may inhibit protease activity and increase the force required to remove human hair, suggesting potential to reduce excessive hair shedding.
research Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat
The authors concluded that diazoxide reduces undesirable side effects compared to minoxidil while increasing elastic fiber content and decreasing cell number in the aorta, suggesting potential suitability for treating vascular conditions with low arterial elastin and hypertension.
research Nitrogen‐Boosted H 2 O 2 Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration
In this study, researchers developed a polyphenol–amino acid nanozyme capable of controlled hydrogen peroxide delivery, which effectively activated hair follicles via oxidative stress in a mouse model, suggesting a potential non-pharmacological treatment for alopecia.
research Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin
This study identified a genetic variant in the CTS6 gene associated with a hypotrichosis syndrome, emphasizing the significant role of cystatin M/E in hair and skin health.
research Effects of combined use of keratinolytic enzymes and sugarcane fibre on the hairball excretion in cats
This study found that the combined use of sugarcane fibre and keratinolytic enzymes reduced hairball excretion in cats.
research Œdème angioneurotique sans anomalie de l’inhibiteur de la C1 estérase : efficacité de l’acide tranexamique
This review highlights the potential benefits of spironolactone in dermatology, particularly for female acne, supporting its safety over long-term use without extensive testing, but presents no new clinical results.
research LEKTI: Netherton Syndrome and Atopic Dermatitis
This article discusses research about Netherton syndrome, highlighting its contributions to understanding epidermal structure, immune responses, and processes like atopic dermatitis, but it reports no new clinical findings.
research Antianaphylactic activity of alcoholic extract ofEclipta alba
This study found that the alcoholic extract of Eclipta alba exhibited dose-dependent antianaphylactic effects in animal models, possibly due to membrane stabilization and reduced histamine release.
research Recombinant Bacillus subtilis-derived alkaline protease: a novel agent for skin depigmentation and hair follicle neogenesis
research Dermatological drugs, topical agents, and cosmetics
This review discusses the adverse effects of dermatological drugs, topical agents, and cosmetics, reporting no new clinical findings; the authors highlight several concerns such as cancer risk from hair dyes and systemic absorption issues with minoxidil.
research 573 Biomarkers quantifying changes in the hair follicular extracellular matrix are elevated in patients with alopecia
Changes in hair follicle structure may help diagnose and monitor alopecia.
research A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report
This paper describes a case of epidermolysis bullosa simplex with muscular dystrophy associated with a novel PLEC mutation and diffuse alopecia, highlighting a potential genetic link that remains uncertain.
research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?
This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.
research Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways
This study found that ILK/ELMO2 complexes in epidermal keratinocytes are selectively activated by epidermal growth factor to induce cell migration, unlike with other growth factors.
research Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery
This study describes a method to create keratin hydrogels with adjustable erosion rates by mixing different ratios of keratose and kerateine, enabling controlled release of therapeutic agents like insulin-like growth factor 1.
research ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
This study found that ALKBH5 plays a critical role in wound re-epithelialization by enhancing the stability of PELI2 mRNA, and its absence delays wound healing. Supplementation with PELI2 can partially rescue this delay, pointing to potential new therapies for stubborn wounds.
research Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery
research Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells
This study found that escin acts as a natural agonist of the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells by promoting the degradation of GSK-3β, highlighting its potential therapeutic use for conditions like androgenetic alopecia and vitiligo.
research Localization of Type I Human Skin Collagenase in Developing Embryonic and Fetal Skin
research 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin
This study identified a mutation in the CST6 gene linked to a rare syndrome with symptoms affecting hair and skin, revealing cystatin M/E's role in maintaining epidermal homeostasis and hair follicle development.
research Cutaneous asthenia (Ehlers–Danlos syndrome) in a cat
This report describes the first documented case of cutaneous asthenia in a crossbred spayed cat from Turkey, characterized by hyperelastic skin, alopecia, and an ulcerative wound.