Lekti: Netherton Syndrome And Atopic Dermatitis

The document discussed the role of LEKTI in Netherton syndrome and its implications for atopic dermatitis. Netherton syndrome, characterized by ichthyosis, atopy, and trichorrhexis invaginata, was linked to mutations in the SPINK5 gene, which affected the serine protease inhibitor LEKTI. This discovery highlighted LEKTI's importance in epidermal barrier function and immunity, influencing high serum IgE levels and atopic symptoms. Further research identified LEKTI as a regulator of epidermal protease activity, with implications for the degradation of desmoglein 1 and the matriptase-pro-kallikrein pathway. These findings advanced the understanding of epidermal structure and immune processes, contributing to insights into atopic dermatitis.