Dermatological Drugs, Topical Agents, and Cosmetics

The document discussed various dermatological drugs, topical agents, and cosmetics, highlighting their uses and associated risks. Dimethyl fumarate was used for psoriasis treatment by inhibiting cell proliferation and reducing cell adhesion. Hair dye use, particularly before 1980, was linked to an increased risk of non-Hodgkin’s lymphoma in a study with 1321 cases and 1057 controls. Photodynamic therapy caused significant pain, especially during the second treatment, as observed in 38 patients. Capillary leak syndrome, a serious condition, was reported in a patient using acitretin for pustular psoriasis. Tacalcitol, a vitamin D analogue for psoriasis, could cause hypercalcemia, as seen in a young man who developed severe symptoms after prolonged use. The document also mentioned the development of solid lipid nanoparticles for improved drug delivery in topical applications.