Dermatological Drugs, Topical Agents, and Cosmetics

    January 2011 in “ Side effects of drugs annual ”
    Ida Duarte, Rosana Lazzarini, Anita Rotter, Clarice Marie Kobata
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    TLDR Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.
    The document reviewed the safety and efficacy of dermatological drugs, topical agents, and cosmetics. It included results from studies on tretinoin and tacalcitol. A study with 51 participants showed no phototoxic or photoallergic reactions to tretinoin 0.05% in a new gel formulation, confirming its safety regarding sun exposure. Another study with 72 participants supported these findings. However, a separate double-blind study with 80 patients found that tacalcitol had no significant effect on repigmentation or lesion size reduction in non-segmental vitiligo, and no serious adverse reactions were reported. These studies help clarify the safety and potential effectiveness of these dermatological treatments.
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