1 citations
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November 2023 in “Journal of Spinal Cord Medicine” This study suggests that IT PEP injection may have beneficial effects after spinal cord injury, but additional research is necessary to better understand and optimize its clinical application.
June 2018 in “The Journal of Sexual Medicine” In this study, finasteride was found to significantly reduce DHT levels and affect spermatogenic markers in rats, while DA-9401 co-treatment indicated potential ameliorative effects.
9 citations
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism”
May 2018 in “Reactions Weekly” Finasteride treatment for hair loss can cause erectile dysfunction.
February 2020 in “Definitions” This study found that finasteride treatment may decrease contraction of seminal vesicle tissue and alter some semen parameters in male rabbits.
1 citations
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March 2009 in “The Journal of Urology” This review discusses trials on therapies for benign prostatic hyperplasia and reports that combination treatment is more effective than monotherapy for symptom relief and slowing disease progression in men with moderate to severe symptoms and enlarged prostate glands.
April 2017 in “The Journal of urology/The journal of urology” This Cochrane review reports that 5-alpha reductase inhibitors may slightly reduce urological symptoms and acute urinary retention risk compared to placebo, with a possible small reduction in surgical intervention need compared to alpha blockers.
June 2011 in “British Journal of Urology” This review discusses the challenges in developing combination therapies for urological conditions and notes that regulatory requirements and financial disincentives hinder progress, without presenting new clinical findings.
16 citations
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January 2017 in “Asian journal of andrology/Asian Journal of Andrology” This study found that older age at puberty may be associated with lower semen quality and altered reproductive hormone levels in young men, though only some results were statistically significant.
This article reviews the role of hormones in human penis development and associated conditions due to hormonal imbalances, but reports no new findings, suggesting hormone replacement can manage some conditions.
195 citations
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February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
30 citations
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July 2001 in “BJUI” Combination therapy improves urinary flow and reduces residual urine, but needs better stent design.
June 2018 in “The Journal of Sexual Medicine” Low-intensity shock wave therapy is effective in treating erectile dysfunction in diabetic patients.
April 2010 in “The Journal of Urology” Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.
137 citations
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January 2000 in “Skin Pharmacology and Physiology” This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.
October 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that finasteride induced infertility and increased endoplasmic reticulum stress in rats, but these effects were mitigated by DA-9401 administration.
1 citations
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May 2019 in “The Journal of Sexual Medicine” This case report describes two women experiencing hormonally associated vestibulodynia and female arousal disorder, potentially linked to the use of spironolactone for androgen-mediated cutaneous disorders.
September 2011 in “Urology” This study aimed to identify characteristics of patients who fail to void during pressure-flow studies, which limits the determination of the cause behind their lower urinary tract symptoms.
January 2025 in “Biomedicines” In this study, female rats given high doses of testosterone showed decreased endometrial thickness and lower mRNA levels of components in the LIF signalling pathway, indicating that excessive testosterone may negatively impact endometrial receptivity and potentially affect fertility.
April 2014 in “The Journal of Sexual Medicine” This publication compiles abstracts from the 19th Annual Fall Meeting of the Sexual Medicine Society of North America, highlighting advancements and discussions in various areas of sexual medicine without reporting new research results.
17 citations
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January 1998 in “Neurourology and Urodynamics” This report describes a case of adrenomyeloneuropathy where neurogenic bladder dysfunction developed, attributed to demyelinating lesions in the patient's peripheral nerves, spinal cord, and cerebral white matter.
5 citations
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May 2011 in “Movement Disorders” Finasteride significantly reduced tics and obsessive-compulsive symptoms in Tourette syndrome patients.
18 citations
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March 2014 in “Journal of Pharmacological and Toxicological Methods” This study found that ovariectomized and finasteride-treated rats showed significant tear film deficiency and downregulation of sex steroid receptors in ocular tissues, suggesting potential models for studying dry eye disorders.
January 2023 in “The Annals of african surgery” This review concludes that preoperative hormonal stimulation with testosterone or DHT may help increase penile length and glans circumference, easing hypospadias surgery and potentially reducing postoperative complications.
September 2024 in “Reproduction and Fertility” This review highlights the limited effectiveness of current unlicensed treatments for male subfertility, like hormonal therapy and antioxidants, and emphasizes new drug discovery methods such as high-throughput screening and drug repurposing to improve treatment development for male subfertility.
2 citations
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February 2021 in “Brain Research” This study found that testosterone replacement in castrated male rats counteracted endotoxemia-induced arterial baroreflex dysfunction without significantly affecting neuroinflammation.
20 citations
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April 2023 in “The Journal of Urology” This study found that two injections of platelet-rich plasma were safe but no more effective than placebo in treating mild to moderate erectile dysfunction.
16 citations
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April 1978 in “Genetics Research” This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.
January 2024 in “Saudi pharmaceutical journal” In this study, the researchers developed and optimized a bilayer tablet containing Tamsulosin and Finasteride, achieving sustained and immediate drug release with favorable release kinetics, including first-order and anomalous diffusion mechanisms, through in vitro testing.
6 citations
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November 2023 in “Lara D. Veeken” The authors concluded that sexual dysfunction is highly prevalent yet often overlooked in patients with autoimmune rheumatic disease, and they emphasize the need for increased awareness, research, and integration into clinical practice.