Induction of Secreted WNT Factor WISP1/CCN4 by Human Prostate Stromal Cells Under Microenvironmental Hypoxia

    April 2010 in “ The Journal of Urology ”
    Matthew Tanner, Mengqian Chen, Elina Levina, Richard Carkner, Ralph Buttyan
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    TLDR Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.
    The document reports on two studies, with the first showing that androgen can regulate prostate blood flow in castrated male Wistar rats (n=7) through a non-classical signal transduction pathway, as evidenced by increased blood flow following testosterone-BSA injection, which was inhibited by bicalutamide. The second study, a case-control with 30 early-onset androgenetic alopecia (AGA) patients and 30 controls, found that AGA is associated with increased prostate volume and urinary symptoms, but not with testosterone, albumin, or SHBG levels, suggesting a shared androgen-dependent mechanism in AGA and prostate growth. Additionally, the document mentions, but does not fully summarize, a study on WISP1/CCN4 induction by hypoxic prostate stromal cells.
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