Detection of Membrane Androgen-Binding Site in Living Rat Prostate and Evaluation of Its Role in Prostate Blood Flow Regulation

April 2010 in “ The Journal of Urology ”

Yasuhiro Shibata, Seiji Arai, Bunzo Kashiwagi, Kazuto Ito, Sato Honma, Kazuhiro Suzuki

androgen-binding site prostate gland testosterone conjugate BSA-FITC-T prostate blood flow anti-androgen bicalutamide androgens non-classical signaling pathway testosterone Casodex

TLDR The research found that androgens help control blood flow in the rat prostate through a specific binding site.

The study, involving 7 castrated adult male Wistar rats, demonstrated the presence of a membrane androgen-binding site in the prostate gland and its role in regulating prostate blood flow. The rats were injected with a membrane-impermeable testosterone conjugate (BSA-FITC-T), which led to a significant increase in prostate blood flow that was blocked by the anti-androgen bicalutamide. This suggests that androgens may regulate prostate blood flow through a non-classical signaling pathway, as indicated by the rapid response and the inhibition by bicalutamide.

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