Detection of Membrane Androgen-Binding Site in Living Rat Prostate and Evaluation of Its Role in Prostate Blood Flow Regulation
April 2010
in “
The Journal of Urology
”
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Studysummary This study found that ureteroileal anastomosis with direct intraluminal visualization had a 4.2% stricture rate, which compares favorably to other techniques with rates between 3.5% and 11.1%. Our plain-language summary of this paper — not a Tressless recommendation.
The study, involving 7 castrated adult male Wistar rats, demonstrated the presence of a membrane androgen-binding site in the prostate gland and its role in regulating prostate blood flow. The rats were injected with a membrane-impermeable testosterone conjugate (BSA-FITC-T), which led to a significant increase in prostate blood flow that was blocked by the anti-androgen bicalutamide. This suggests that androgens may regulate prostate blood flow through a non-classical signaling pathway, as indicated by the rapid response and the inhibition by bicalutamide.
