Androgenic Modulation of Arterial Baroreceptor Dysfunction and Neuroinflammation in Endotoxic Male Rats

    February 2021 in “ Brain Research ”
    Marwa Ahmed Sallam, Sahar M. El-Gowilly, Mahmoud M. El-Mas
    Image of study
    TLDR Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.
    The study explored how androgenic hormones influence arterial baroreflex sensitivity and neuroinflammation in male rats experiencing endotoxic shock. It was found that lipopolysaccharide (LPS) decreased baroreflex sensitivity and increased inflammation in the heart and brainstem, which was slightly mitigated by castration. Testosterone replacement in castrated rats improved baroreflex sensitivity for phenylephrine but not for sodium nitroprusside and increased cardiac inflammation without affecting brainstem inflammation. The use of degarelix, a gonadotropin-releasing hormone receptor blocker, prevented the negative effects of LPS on baroreflex sensitivity and inflammation. The study concluded that testosterone has a specific role in modulating the effects of LPS, and that neither dihydrotestosterone (DHT) nor estrogen, which are derived from testosterone, are involved in this modulation. The beneficial effects of blocking the hypothalamic-pituitary-gonadal axis with degarelix suggest a potential therapeutic approach for endotoxemia. The study involved 84 adult male Wistar rats.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community FINASTRIDE and switch to DUTASTRIDE, my experience

      in Progress Pictures  135 upvotes 2 months ago
      The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

      community What Private blood test should I take?

      in Finasteride/Dutasteride  7 upvotes 3 months ago
      A user in the UK seeks advice on blood tests before starting Finasteride and Minoxidil for hair loss. Recommended tests include thyroid function, hormone levels, liver and kidney function, and vitamin and mineral levels.

      community 21 months on topical minoxidil and full HRT

      in Transgender  214 upvotes 6 months ago
      The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.

      community Saying creatine causes loss on fin/dut makes no sense and this is why

      in Finasteride/Dutasteride  42 upvotes 9 months ago
      The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  82 upvotes 11 months ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

    Similar Research

    5 / 1000+ results