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GlossaryGonadotropin-Releasing Hormone Antagonists

medications that block hormone signals to reduce sex hormone production

Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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research Androgenic Modulation of Arterial Baroreceptor Dysfunction and Neuroinflammation in Endotoxic Male Rats

2 citations , February 2021 in “Brain Research”

Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.

research Hormonal Treatment of Acne Vulgaris: An Update

46 citations , September 2016 in “Clinical, Cosmetic and Investigational Dermatology”

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content

research Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content

82 citations , February 1989 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

research Clinical Management of Youth with Gender Dysphoria in Vancouver

116 citations , December 2013 in “The Journal of Pediatrics”

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

research Endocrinology Overview: Male Reproductive Endocrinology and HPT Axis

January 2018 in “Elsevier eBooks”

The document explains how male reproductive hormones work and affect the body.

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community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 125 upvotes 2 years ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 112 upvotes 3 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community My Estradiol Level on Finasteride

in Research/Science 17 upvotes 9 months ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community What are your thoughts on pre-finasteride blood work?

in Finasteride/Dutasteride 1 upvotes 2 years ago

The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.

community Testosterone is 1600, would taking low dose anti-androgens be a viable treatment option for people who’s T spikes on DHT-blockers?

in Treatment 46 upvotes 2 years ago

The post and conversation are about the user's high testosterone levels and their worsening hair loss despite trying various treatments. They are considering using low doses of anti-androgens to lower their testosterone levels as a potential solution.

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