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    Glossary Ectodysplasin A Receptor

    protein crucial for hair, teeth, and gland development

    The Ectodysplasin A Receptor (EDAR) is a protein that plays a crucial role in the development of hair, teeth, and certain glands. Mutations in the EDAR gene can lead to conditions like hypohidrotic ectodermal dysplasia, which is characterized by sparse hair, missing teeth, and reduced ability to sweat.

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    Research 30 of 317

    1. Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form Human mutation · 2008 · 98 citations
    2. Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness Human Genetics · 2009 · 42 citations
    3. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    4. Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark Research Square (Research Square) · 2021 · 3 citations
    5. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development 2012 · 48 citations
    6. A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia Human genetics · 2008 · 89 citations
    7. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    8. Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin Frontiers in physiology · 2018 · 37 citations
    9. p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss FEBS Letters · 2010 · 37 citations
    10. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations
    11. EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes 2020 · 12 citations
    12. Lgr5 Stem Cells and Potential Treatments for Hair Loss Theoretical and Natural Science · 2026
    13. miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network Frontiers in Cell and Developmental Biology · 2022
    14. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    15. A review of genetic researches of and rogenic alopecia Int J Genet · 2016
    16. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    17. The biology of hair diversity International Journal of Cosmetic Science · 2013 · 47 citations
    18. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    19. The Roles of EDA2R in Ageing and Disease Aging Cell · 2025 · 1 citations
    20. Significant Correction of Disease after Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007 · 109 citations
    21. Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene Experimental Dermatology · 2010 · 26 citations
    22. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005 · 195 citations
    23. Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis Clinical and Experimental Dermatology · 2011 · 41 citations
    24. Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele Cancer Causes & Control · 2017
    25. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    26. Stimulation of ectodermal organ development by Ectodysplasin-A1 Developmental Biology · 2003 · 249 citations
    27. Ectodysplasin Signaling in Cutaneous Appendage Development: Dose, Duration, and Diversity 2009 · 9 citations
    28. Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling Seminars in Cell & Developmental Biology · 2012 · 300 citations
    29. Feather arrays are patterned by interacting signalling and cell density waves PLoS Biology · 2019 · 133 citations
    30. Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats Scientific Reports · 2025 · 1 citations