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This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

This study developed a new method for detecting 30 hormones in anti-aging functional foods, demonstrating good sensitivity and reliability, and identified seven hormones in four out of 14 samples tested.

This study found that OPC-17116 can be reliably detected in hair, suggesting it can serve as an index of drug exposure and a time-marker in hair analysis.

This study found that chronic administration of finasteride affected the isotopic composition of testosterone and nandrolone metabolites, impacting the drug-testing outcomes in athletic contexts.

This study conducted a large-scale comparison using FAERS data to assess the post-marketing safety profiles of spironolactone, eplerenone, and finerenone, finding unique adverse event patterns for each drug and highlighting the need for personalized safety monitoring and further investigation in other pharmacovigilance databases.

This study suggests that caffeine may enhance hair growth and be beneficial for cosmetic applications due to its high binding affinity to keratin, but further validation is needed.

This chapter discusses phase transitions in various pharmaceutical examples and does not present any new research findings.

This study found that co-administration of ketoconazole significantly altered the pharmacokinetics of dutasteride in rats, suggesting an interaction potential between dutasteride and azole antifungal drugs.

This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.

This study found that isorhamnetin, a compound from the Rampai plant, showed a lower affinity energy in molecular docking tests compared to Minoxidil, indicating potential as an androgen receptor antagonist for alopecia therapy in silico, with favorable pharmacokinetic characteristics in ADME-Tox predictions.

This study found that caffeine and flufenamic acid penetrated porcine skin more effectively through hair follicles, while the importance of the follicular pathway varied for other substances tested.

In this study, the 40-MBR system was shown to enhance drug-screening efficiency by providing reliable, real-time monitoring of cell conditions in 3-D cultures compared to traditional methods.

This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.

This study found that finasteride's solubility and bioavailability were improved when using a dimethyl-β-cyclodextrin inclusion complex compared to the drug alone.

This study developed a highly sensitive fluorescent assay for measuring enzyme activity in single hair follicles, allowing the efficient analysis of over 100 samples per day.

This theoretical study suggests that certain cannabinoid derivatives could potentially be effective as androgen receptor and 5α-reductase enzyme inhibitors, indicating they may be promising candidates for prostate cancer treatment based on their higher affinity to target proteins compared to standard drugs.

This study analyzed data from the FDA Adverse Event Reporting System and found that finasteride had the highest reporting frequency and signal strength for drug-induced erectile dysfunction among 734 drugs, with compound preparations posing higher risks than single ingredients.

This study investigated the potential of nutmeg-derived phytochemicals as anti-alopecia agents using molecular docking and simulations, finding that geranylgeraniol exhibited significant binding stability and potential efficacy against androgenetic alopecia comparable to finasteride and superior to minoxidil.

This review discusses various patent articles on microemulsion carriers in drug delivery systems and reports no new empirical findings.

This study found that targeting the hair follicle can be increased by using lipophilic drugs combined with surfactant solutions and propylene glycol.

This article reviews various models used in dermatopharmacology research, exploring their applications in studying skin conditions and hair growth, but reports no new findings.

Antisense oligonucleotides show promise for treating Myotonic Dystrophy type I.

This study developed a spectrophotometric method to determine minoxidil in pharmaceuticals, creating a highly sensitive, simple, and cost-effective approach using a synthesized charge transfer complex with a notable absorption peak at 505 nm.

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

This study identified seven novel CYP17A1 inhibitor scaffolds as potential leads for treating polycystic ovary syndrome through an in silico approach, demonstrating favorable interactions, drug-like properties, and predicted bioactivities warranting further experimental validation.

This review discusses the relevance of human androgen receptor action in sports doping and examines the potential of cell-based biological assays for detecting androgenic anabolic steroid use, without presenting new research findings.

This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.

This study reported that clozapine and its metabolite showed a preference for binding to pigmented hair, but were also detectable in non-pigmented hair of patients with Parkinson's, with high correlations between dose and hair concentration.

This study identified a series of novel β-glucuronidase inhibitors that may help mitigate adverse effects of first-line anti-cancer drugs by targeting gut bacteria, based on virtual high-throughput screening findings.