TLDR Measuring OPC-17116 in hair can reliably indicate drug exposure and timing.
The study investigated the use of hair samples to measure exposure to a new antimicrobial quinolone, OPC-17116, in healthy male volunteers. Hair samples were collected at 1-month intervals for up to 5 months. The study involved 5 subjects taking a single 400 mg dose and 6 subjects taking repeated doses of 400 mg twice daily for 6.5 days. Additionally, 4 subjects received 300 mg three times daily for 2 days. The drug was detected in hair segments corresponding to the administration period, with no significant diffusion along the hair shaft over time. These results suggested that measuring OPC-17116 in hair could serve as an effective index of drug exposure and a time-marker for analyzing other drugs.
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