March 2025 in “Scientific Reports” This study found a complex relationship between cumulative doses of 5-ARIs and all-cause mortality among BPH or AGA patients, with lower doses linked to higher suicide rates and higher doses reducing cardiovascular mortality risk.
April 2017 in “Journal of Investigative Dermatology” This study observed that a 3D culture model of hair follicle cells showed an anagen-like phase between days 3 to 6 and transitioned to a catagen-like phase by day 7, highlighting cell differentiation and structural development over time.
69 citations
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February 2008 in “The American journal of pathology” This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.
53 citations
,
April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
2 citations
,
September 2024 in “Journal of the American Academy of Dermatology” Higher monocyte counts may predict poor response to adalimumab in hidradenitis suppurativa patients.
1 citations
,
May 2023 in “International Journal of Applied Pharmaceutics” In this study, the researchers developed a novasome vesicle carrying bovine placenta extract, which demonstrated superior hair growth effects in rats compared to traditional minoxidil and PE-loaded liposomes, and showed good stability and physical characteristics over 90 days at 4°C.
November 2025 in “The Journal of Dermatology” This study demonstrated that a mouse model of telogen effluvium induced by lipopolysaccharide was effective for evaluating the therapeutic effects of topical minoxidil, which accelerated hair regrowth in treated mice.
April 2025 in “Journal of Investigative Dermatology” This study found that elevated luteinizing hormone levels were significantly associated with female pattern hair loss, and implicated LH/LHR signaling in the aging and damage of hair follicles.
January 2023 in “Skin appendage disorders” This review discusses the potential of low-dose oral minoxidil as a safe and effective treatment for certain hair disorders, including alopecia, but reports no new clinical results.
64 citations
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September 2006 in “International journal of epidemiology” This article discusses a proposed "Darwinian" model of carcinogenesis and emphasizes that cancer prevention involves more than avoiding mutagens, as gene-environment interactions are complex and non-linear.
26 citations
,
June 2024 in “Frontiers in Immunology” The authors discussed that SOCS1 and SOCS3's inhibition of JAKs plays a significant role in the development of JAK inhibitor drugs for skin inflammatory diseases and malignancies.
92 citations
,
January 1999 in “Physics in Medicine and Biology” This study developed and validated a computational model to optimize skin precooling methods for minimizing thermal damage during laser procedures.
41 citations
,
February 2021 in “Translational research” This review discusses the role of noncoding RNAs (ncRNAs) in radiation response and highlights their potential as biomarkers for assessing radiation damage, but reports no new clinical results.
41 citations
,
July 2012 in “Stem Cells and Development” This study found that low-dose UVB radiation enhances the survival, migration, and hair growth-promoting capacity of adipose-derived stem cells in mice through the generation of reactive oxygen species.
37 citations
,
September 2018 in “Journal of the American Academy of Dermatology” This letter reports a series of cases where the use of ruxolitinib at a lower dose than previously studied led to hair regrowth in patients with severe alopecia areata.
32 citations
,
January 2017 in “Physiology & Behavior” This study found that in rodent diabetes models, measuring corticosterone levels in new growth hair was more sensitive to hyperglycemia-induced changes than using old hair or serum samples.
29 citations
,
March 2022 in “Biomedicines” This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.
25 citations
,
June 2023 in “Biomedicines” This review examined how COVID-19 infection and vaccination might affect sexual activity, sex hormones, and menstrual cycles in men and women, and found no evidence of COVID-19 transmission via semen.
15 citations
,
November 2020 in “Pharmaceutics” In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.
10 citations
,
September 2021 in “JAMA Dermatology” This study reports that persistent chemotherapy-induced alopecia in breast cancer patients frequently resembles androgenetic alopecia, and treatment with minoxidil, alone or with antiandrogens, improved hair density in many cases.
9 citations
,
January 2022 in “Biology” This study concluded that male mice are more susceptible to valproic acid-induced autism spectrum disorder than female mice, with noticeable differences in brain histoarchitecture and receptor protein levels.
7 citations
,
February 2025 in “Stem Cell Research & Therapy” In a study using a mouse model, HF-MSCs were reported to enhance ovarian function in cyclophosphamide-induced premature ovarian failure more effectively than HU-MSCs, potentially by preventing ferroptosis in granulosa cells via the KEAP1/NRF2/HO-1 pathway.
7 citations
,
December 2015 in “Journal of thermal biology” This study used numerical models to explore the cooling power required by different scalp cooling devices to prevent chemotherapy-induced hair loss, finding that coolant temperature significantly influences scalp tissue temperatures.
5 citations
,
September 2022 in “Journal of Investigative Dermatology” This review discusses factors affecting wound-induced hair neogenesis in mice and reports no new results; it aims to facilitate meaningful comparisons of experiments across different laboratories.
4 citations
,
November 2021 in “Molecular Medicine Reports” In this study on a mouse model of vitiligo, NB-UVB/ADSC combination therapy improved oxidative stress and calcium homeostasis, but the protective effect was reversed by inhibiting Nr2 signaling.
2 citations
,
July 2025 in “RMD Open” This study found that IL-1 blockers are effective for SURF and identified predictors of colchicine resistance, emphasizing the need for refined diagnostic criteria and personalized treatment due to the heterogeneity observed within SURF.
2 citations
,
May 2023 in “Biology” This study developed and characterized new mouse models of Pemphigus that mimic different forms of the disease, but treatment with Methyl-Prednisolone showed only partial effectiveness.
1 citations
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November 2017 This chapter reviews classic regeneration models in planarian worms and amphibian limbs, focusing on the role of stem cells, and reports no new experimental results.
In this study, baseline neutrophil-to-lymphocyte ratio (NLR) was associated with predicting early trichoscopic response in patients undergoing PRP-based treatment for non-scarring alopecia.
December 2025 in “Nature Communications” In this study using mouse models, researchers found that elevated IL-17a in aged olfactory epithelium impairs olfactory function, while IL-17a inhibition promotes regeneration and mitigates age-related decline.