Human Hair Follicle-Derived Mesenchymal Stem Cells Improve Ovarian Function in Cyclophosphamide-Induced POF Mice

February 2025 in “ Stem Cell Research & Therapy ”

Jong-Suk Mo, Honggang Hu, Pengdong Li, Ye Yang, Wenchuan Chen, Lei Chen, Jie Qiao, Xiaoying Zhao, Qiuxia Yan, Cairong Chen

human hair follicle-derived mesenchymal stem cells mesenchymal stem cells granulosa cells ferroptosis KEAP1/NRF2/HO-1 pathway

TLDR Human hair follicle stem cells improve ovarian function in mice with damaged ovaries.

The study demonstrates that human hair follicle-derived mesenchymal stem cells (HF-MSCs) can enhance ovarian function in mice with premature ovarian failure (POF) induced by cyclophosphamide, showing superior effects compared to human umbilical mesenchymal stem cells (HU-MSCs). The beneficial effects of HF-MSCs are likely due to the inhibition of ferroptosis in granulosa cells via the KEAP1/NRF2/HO-1 pathway.

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research Intravenous Transplantation of Human Hair Follicle-Derived Mesenchymal Stem Cells Ameliorates Trabecular Bone Loss in Osteoporotic Mice

8 citations , March 2022 in “Frontiers in Cell and Developmental Biology”

Human hair follicle stem cells can help treat bone loss in osteoporosis.

Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

research Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

73 citations , August 2011 in “Stem Cell Research”

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.