Anti-Aging Potential of Platelet Rich Plasma: Evidence from Osteoarthritis and Applications in Senescence and Inflammaging

August 2023 in “ Bioengineering ”

Shen Hwa Vun, Neelam Iqbal, Elena Jones, Payal Ganguly

platelet-rich plasma PRP androgenic alopecia hair count hair density hair thickness

TLDR PRP may help with aging and osteoarthritis, improving tissue repair and reducing surgery risk.

The document discusses the potential of Platelet Rich Plasma (PRP) as an anti-aging treatment, particularly in the context of osteoarthritis (OA) and other age-related diseases (ARDs). PRP, which contains over 1100 proteins, has been used to alleviate pain, promote tissue regeneration, and repair in dermatological and orthopaedic applications. The document suggests that PRP has potential anti-aging properties that can be exploited for age-related changes and the treatment of several ARDs. A systematic review and meta-analysis of 10 randomised controlled trials (RCTs) with 652 patients found that PRP can reduce fracture healing time, enhance bone mineral density, and decrease the risk of revision surgeries. PRP has also been used in dermatology and plastic surgery, with multiple RCTs reporting increased hair count, density, and thickness among patients who underwent PRP treatment for androgenic alopecia. However, the exact mechanism of PRP's effect remains to be established. Future research should focus on standardizing PRP formulations, exploring its impact on aging and age-related diseases, and tailoring PRP therapies for each patient or case.

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research Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

18 citations , March 2022 in “Drug design, development and therapy”

Platelet-rich plasma (PRP) may help with various hair loss types, but more research is needed to find the best use method.

research The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial

18 citations , November 2020 in “Journal of The American Academy of Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Platelet-Rich Plasma and Regenerative Dentistry

87 citations , March 2020 in “Australian Dental Journal”

Platelet-rich plasma might help tissue regeneration in dentistry, but results vary and more research is needed.

research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

51 citations , March 2019 in “Journal of cellular physiology”

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

research The Effect of Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia

12 citations , March 2019 in “Journal of Cosmetic Dermatology”

PRP injections improve hair thickness and density in hair loss, but more research needed.

research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

57 citations , March 2019 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma treatment can significantly increase hair count and density in men with pattern baldness, and these improvements can last up to 3 months.

research The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

76 citations , December 2018 in “Aesthetic Plastic Surgery”

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.