Minoxidil Promotes Hair Growth in a Mouse Model of Telogen Effluvium Induced by Lipopolysaccharide

    November 2025 in “ The Journal of Dermatology
    Yuji Tani, Shiro Makihara, Akihisa Morito, Manabu Ohyama
    TLDR Minoxidil helps hair regrow faster in stress-related hair loss.
    This study establishes a new mouse model of telogen effluvium (TE) induced by lipopolysaccharide (LPS) to mimic the condition of excessive hair loss due to stress, such as severe infectious diseases. The research demonstrates that topical minoxidil (tMXD), a known hair growth-promoting medication, effectively accelerates hair regrowth in this model. Mice treated with LPS showed increased interleukin-6 levels and neutrophil counts, leading to a faster transition of hair follicles into the telogen phase. However, when treated with tMXD, these mice experienced quicker and complete hair regrowth compared to controls, highlighting the potential of tMXD as a therapeutic option for TE.
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