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Basonuclin 2 is vital for the development of facial bones, hair follicles, and male germ cells in adult mice, and its absence can lead to dwarfism and abnormal follicles.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Notch signalling helps skin cells differentiate and prevents tumors.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

Mouse Notch is important for determining cell roles in hair follicles.

Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.

Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

TLR4 is important in aging-related diseases and could be a new treatment target.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.

Vitamin D receptor is crucial for bone health and mineral metabolism.

The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.

Notch signaling disruptions can cause various skin diseases.

Fibrodysplasia ossificans progressiva is a rare genetic disorder that causes extra bone growth and symptoms of premature aging.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Vitamin A helps skin stem cells decide their function, aiding in hair growth and wound repair.

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Patched1 helps prevent tumors by controlling cell growth.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Certain IL-18 gene variations may increase the risk of alopecia areata.

The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.

Hair follicle stem cells change states with age, affecting hair growth and aging.

A specific genetic marker is linked to male pattern baldness in Han Chinese men.

The research showed that Vitamin D and its receptor are important for healthy bones and normal hair and skin in rats.