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Orphan drug benefit scores in Germany are influenced by phase III data and lack of alternatives, but not linked to price or discounts.

Microneedles are promising for long-acting drug delivery and can improve patient compliance, but more data is needed to confirm their effectiveness.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Oxygenated micro/nanobubbles speed up burn wound healing in rats.

Hydrogels combined with extracellular vesicles and 3D bioprinting improve wound healing.

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

Stem cells from hair follicles in a special gel show strong potential for bone regeneration.

Peptide hydrogels show promise for healing skin, bone, and nerves but need improvement in stability and compatibility.

Optical Coherence Tomography has potential in diagnosing hair loss and monitoring blood clotting, and could be improved for deeper tissue observation and better hair loss understanding.

OCT can effectively screen and diagnose various medical conditions non-invasively.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.

A model called PM-DBiGRU was developed for analyzing sentiments in drug reviews, and it performed better than other models, but struggled with complex sentences and situations requiring background knowledge.

Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.

Using micro skin tissue columns improves skin wound healing and reduces scarring.

A low-power, fast laser safely reduces hair with minimal pain and few side effects.

Mouse zigzag hair bends form due to a 3-day cycle of changes in hair progenitors and their environment.

The system helps monitor hair properties using RGB video microscopy.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

The document concludes that various clinical methods are used to assess ageing skin and the effectiveness of anti-ageing products.

Researchers found genes that control hair color and growth change before the visible coat color changes in snowshoe hares.

Mathematical modeling can improve regenerative medicine by predicting biological processes and optimizing therapy development.

MRI can effectively image skin structures noninvasively.

A new gel containing minoxidil can treat hair loss effectively, potentially reducing side effects and improving treatment.

Dermoscopy is useful for diagnosing hair loss patterns in dogs.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Glutamic acid helps increase hair growth in mice.

Hair loss might be due to nerve issues, treatable with electric stimulation or acupuncture.