research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes
A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.
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210-240 / 1000+ resultsresearch sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation
Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.
research Melatonin Regulates the Mitogen-Activated Protein Kinase Pathway via the CircMPP5-miR-211-MAPK3 Axis to Induce Secondary Hair Follicle Differentiation and Development in Newborn Cashmere Goat Kids
Melatonin helps improve Cashmere goat hair quality by promoting hair follicle growth through a specific cell signaling pathway.
research MiR-133a-3p and MiR-145-5p Co-Promote Goat Hair Follicle Stem Cell Differentiation by Regulating NANOG and SOX9 Expression
miR-133a-3p and miR-145-5p help goat hair follicle stem cells differentiate by controlling NANOG and SOX9.
research Fate Tracing of DNA-Damaged Hair Follicle Stem Cells and Their Seno-Differentiation Clearance Out of the Niche
Damaged hair follicle stem cells may leave the skin to help maintain youthfulness.
research Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators in Differentiation, Proliferation, and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study
Artemis protein may help control hair growth and health by influencing cell processes.
research Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation
BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.
research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages
The human skin's outer layer has more variety in cell types and development paths than previously thought.
research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation
Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.
research A 5α-Reductase Inhibitor, Finasteride, Increases Differentiation and Proliferation of Embryonal Carcinoma Cell-Derived Neural Cells
research Genome Wide Association Analysis of Root Hair Traits in Rice Reveals Novel Genomic Regions Controlling Epidermal Cell Differentiation
Scientists found new genetic areas that affect how rice root hairs grow and develop.
research Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation
Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.
research Comparison of Three Different Lactic Acid Bacteria-Fermented Proteins on RAW 264.7 Osteoclast and MC3T3-E1 Osteoblast Differentiation
Fermented soy protein may help prevent bone loss by affecting bone cell activity.
research The Early Region of Trichodysplasia Spinulosa Polyomavirus Drives Proliferation, Altered Differentiation, and Ectopic Expression of Hair Follicle Differentiation Markers in Interfollicular Tail Epidermis
The early genes of a specific virus can cause abnormal skin cell growth and hair follicle changes.
research The 532 nm Laser Treatment Promotes the Proliferation of Tendon-Derived Stem Cells and Up-Regulates Nr4a1 to Stimulate Tenogenic Differentiation
A 532 nm laser helps tendon stem cells grow and become tendon-like by increasing Nr4a1 activity, which may speed up tendon repair.
research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation
The estrogen receptor pathway controls hair growth cycles and affects skin cell growth.
research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage
Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
research TGF-β Family Signaling in Stem Cells
TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
research Stem Cells Behind the Barrier: Mechanisms Regulating Epidermal Stem and Progenitor Cell Differentiation
Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.
research Effects of 1α,25-Dihydroxy-Vitamin D3 and Calcipotriol on Organotypic Cultures of Outer Root Sheath Cells: A Potential Model to Evaluate Antipsoriatic Drugs
Vitamin D compounds may help treat psoriasis by promoting skin cell differentiation.
research Characterization of Interfollicular Stem Cells and Early TA Cells During the Transition From Infant to Child Skin
The study concludes that as skin matures from infancy to childhood, there are major changes in cell differentiation, stemness, and growth, leading to a stronger skin barrier in older children.
research Author Response: Interplay of Opposing Fate Choices Stalls Oncogenic Growth in Murine Skin Epithelium
The balance between cell renewal and differentiation controls the growth of cancerous cells in mouse skin.
research The Hair Follicle as a Dynamic Mini-Organ
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins
Hair and nail cells share similar proteins, indicating a common differentiation pathway.
research ATP-Dependent Chromatin Remodeling During Mammalian Development
ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
research Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately
Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
research Topographical and Developmental Studies on Target Sites of 1,25 (OH)₂ Vitamin D₃ in Skin
Vitamin D3 affects cell differentiation in specific skin areas.
research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin
Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)
The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
research From Structural Resilience to Cell Specification: Intermediate Filaments as Regulators of Cell Fate
Intermediate filaments are crucial for cell differentiation and stem cell function.