The 532 nm Laser Treatment Promotes the Proliferation of Tendon-Derived Stem Cells and Up-Regulates Nr4a1 to Stimulate Tenogenic Differentiation
October 2021
in “
Research Square (Research Square)
”
Studysummary In this study, a 532 nm laser at 15 J/cm² increased the proliferation and tenogenic differentiation of tendon-derived stem cells in rats, mediated by Nr4a1 up-regulation. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the effect of low-level laser therapy (LLLT) with a wavelength of 532 nm on the proliferation and differentiation of tendon-derived stem cells (TDSCs) from Sprague-Dawley rats. The ideal energy was determined to be 15J/cm2. The results showed that this laser treatment improved the proliferation capacity of TDSCs (2.73 ± 0.24 vs. 1.81 ± 0.71, P < 0.05) and significantly increased the expression of genes related to tenogenic differentiation (P < 0.01). The gene Nr4a1 was identified as being involved in the tenogenic differentiation process of TDSCs regulated by the 532 nm laser treatment. The study concluded that a 532 nm laser with 15J/cm2 can regulate the process of TDSC proliferation and tenogenic differentiation by up-regulating Nr4a, potentially accelerating tendon healing.
