Fate Tracing of DNA-Damaged Hair Follicle Stem Cells and Their Seno-Differentiation Clearance Out of the Niche

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    M. Miranda, H. Matsumura, K. Asakawa, T. Kato, Y. Muroyama, M. Higa, L. Tan, Y. Kawamura, E.K. Nishimura
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    TLDR Damaged hair follicle stem cells may leave the skin to help maintain youthfulness.
    The study investigates the fate of DNA-damaged hair follicle stem cells (HFSCs) and their clearance from the niche, particularly in the context of aging and chemotherapy-induced alopecia. Using mouse models that induce DNA double-strand breaks (DSBs) in a small number of stem cells, the researchers observed that DNA-damaged HFSCs are cleared from the epidermal layer, suggesting a transdermal exit. These cells exhibited markers of DNA damage and oxidative stress but did not show typical senescent cell markers like SAβ-gal and p16. The findings suggest a tissue-autonomous mechanism in the hair follicle niche that discards stressed cells, potentially leading to hair follicle miniaturization and hair loss.
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