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570-600 / 1000+ resultsresearch Clinical pearls addressing hair growth and loss in transgender patients on hormone replacement therapy
This commentary highlights that transgender patients are often dissatisfied with standard hormone replacement therapy for hair-related goals, emphasizing the need for dermatologists to provide informed guidance and tailor treatments.
research Analysis of Methyltestosterone and Testosterone Propionate in Dried Blood Spots After Transdermal Application
This study found that after application of a testosterone cream containing 17α-methyltestosterone and testosterone propionate, these compounds could be detected in dried blood spots up to 97 hours post-application, potentially leading to sample contamination during fingertip puncture.
research 27th Meeting of the Society of Hair Testing (SoHT)
This meeting underscored that hair testing is a crucial and evolving area in forensic and toxicological science, emphasizing advancements in analytical methods and its importance in public health and legal medicine.
research A phosphoinositide-mediated switch of GET pathway receptor dimerization in Arabidopsis
This study identifies the PI4P-RHD4 module as a key regulator of GET pathway receptor dynamics in Arabidopsis, affecting TA protein insertion and root hair growth.
research Effect of DNA aptamer through blocking of negative regulation of Wnt/β‐catenin signaling in human hair follicle dermal papilla cells
This study found that WD-aptamer increased β-catenin expression and promoted human hair follicle dermal papilla cell proliferation by interfering with the CXXC5-Dvl1 interaction in the Wnt signaling pathway.
research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway
This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.
research Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities
This report presents the Taiwanese Dermatological Association's 2016 consensus on defining and managing skin toxicities from EGFR-TKI treatments, providing comprehensive guidelines for clinicians in Taiwan.
research Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles
This study found that the proteins GDNF, NTN, GFRα-1, GFRα-2, and c-Ret are differentially expressed during various stages of the human hair follicle cycle, with potential implications for hair biology.
research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression
This study found that genetic ablation of Tet genes in mice led to changes in hair structure and keratin gene expression, indicating a role for Tet-mediated 5hmC DNA oxidation in hair follicle development and cycling.
research O-T-C Hair Preparations
research Solubilizing steroidal drugs by β-cyclodextrin derivatives
This study found that anionic HSES achieved high complexation efficiencies with various steroids, significantly enhancing their solubility, while specific β-cyclodextrin thioethers showed selective binding to testosterone and estradiol.
research 085 Coordinate expressions of cyclin-dependent kinase inhibitors and high sulfur protein in human hair follicles
research Experience in improving the results of treating scalp defects using the FUE method with DHI
This study reports that hair transplantation using follicular unit extraction and direct hair implantation can effectively restore scalp hair in post-burn alopecia, achieving natural hair direction and satisfactory growth density.
research Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function
Hairless protein helps control hair growth by regulating vitamin D receptor activity.
research Cryogelation of human hair keratins
This study demonstrated that cryogelation of human hair keratin allows the development of 3D scaffolds with tunable properties, supporting cell adhesion and proliferation for potential biomedical applications.
research Is Prenatal Sex Hormone Balance a Risk Factor for the Development of Hidradenitis Suppurativa
In this cross-sectional study, researchers observed that patients with hidradenitis suppurativa, particularly women, had lower 2D:4D finger length ratios compared to healthy controls, suggesting a potential link to prenatal androgen exposure and disease severity, though further prospective research is needed to confirm this hormonal impact.
research Faculty Opinions recommendation of Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
Vitamin D receptor is key to hair growth, not vitamin D itself.
research A comparative study of Aldactone® and Diane® in the treatment of hirsutism
This study suggests that Aldactone may be more effective than Diane in reducing hair growth, despite having minimal impact on hormone levels.
research DTC pharmaceutical advertising: the debate’s not over
This review discusses consumers' positive attitudes towards direct-to-consumer pharmaceutical advertising, highlighting its impact on patient engagement despite physicians' mixed opinions on its influence on the doctor-patient relationship.
research Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens)
The researchers reported that the rat Hershberger assay reliably detected endocrine-disrupting effects of finasteride, procymidone, and 17α-methyltestosterone, validating the assay's sensitivity for identifying hormonal activity.
research Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells
This study suggests that promoting HIF-1a expression in dermal papilla cells could enhance trichogenic gene expression, offering a potential therapeutic target for hair loss treatment.
research Distribution of 1,25-dihydroxyvitamin D3[22-oxa] in vivo receptor binding in adult and developing skin
In this study, OCT showed strong nuclear binding in certain skin cells, suggesting similar genomic effects to vitamin D with potential therapeutic benefits due to its lower calcaemic effect.
research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone
Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.
research [Analysis of steroids and binding proteins in the blood of women with androgenetic alopecia].
In this study, Diane treatment in women with androgenetic alopecia led to normalization of hormone levels and improved hair condition, including less greasiness and reduced hair loss.
research Androgenetic Alopecia: A Revolutionary Thermal Stress Model - DHT is Not the Culpritأ
This study suggests that male pattern baldness is primarily caused by heat stress in the brain rather than DHT toxicity, and personal experiments with menthol cooling have shown significant reduction in hair loss.
research Evaluation of Efficacy of Water-Soluble Fraction of Rhus semialata Gall Extract and Penta-O-Galloyl-β-D-Glucose on Mitigation of Hair Loss: An In Vitro and Randomized Double-Blind Placebo-Controlled Clinical Study
In this study, the researchers found that the water-soluble fraction of Rhus semialata gall extract and its component Penta-O-Galloyl-β-D-Glucose promoted hair growth in human dermal papilla cells, and clinical trials supported these findings, showing improved hair density and appearance compared to placebo.
research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.
This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.
research Hair removal in hirsute women with normal testosterone levels: a randomized controlled trial of long-pulsed diode laser vs. intense pulsed light
In this study, hirsute women with normal or medically normalized testosterone levels experienced similar, though declining, hair reduction from both intense pulsed light and long-pulsed diode laser treatments over six months.
research Hypotrichosis with juvenile macular dystrophy
This case report describes a 4-year-old girl with hypotrichosis and juvenile macular dystrophy, linked to mutations in the cadherin 3 gene affecting P-cadherin expression.