TLDR OCT binds strongly to hair sheath cells and may affect skin and hair growth with fewer side effects than vitamin D3.
In the 1995 study, researchers examined the binding sites of oxa-calcitriol (OCT) in the skin of adult and neonatal rats to explore its potential effects on skin and hair follicle function. They found that OCT had the strongest binding in the outer hair sheaths, with 1.5 to 3.2 times higher binding than in epidermal keratinocytes. The distribution of OCT receptors was similar to that of 1,25-dihydroxyvitamin D3 but differed from estradiol. The study suggests that OCT may influence keratinocyte proliferation, differentiation, hair growth, and sebaceous gland activity, and could have therapeutic applications due to its lower calcaemic effect compared to 1,25-dihydroxyvitamin D3.
10 citations,
October 1993 in “Archives of dermatological research” Vitamin D compounds may help treat psoriasis by promoting skin cell differentiation.
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70 citations,
November 1984 in “Cell & tissue research/Cell and tissue research” Vitamin D3 affects cell differentiation in specific skin areas.
October 2011 in “Journal of dermatology” A man with a rare skin condition and a new gene mutation developed high calcium levels due to his treatment.
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97 citations,
September 2006 in “Pharmaceutical Research” No treatment fully prevents hair loss from chemotherapy yet.
277 citations,
July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
1308 citations,
March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
48 citations,
February 2017 in “Journal of Cosmetic Dermatology” The conclusion is to use scalp cooling, gentle hair care, and treatments like minoxidil for managing hair loss from chemotherapy, and stresses the need for more research and collaboration in this area.
