research Topical MK-386, an Inhibitor of 5α-Reductase Type I, Suppresses Sebum DHT
MK-386 reduces sebum DHT levels.
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research Classification Scale for Male and Female Androgenetic Alopecia
Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.
research 5α-Reductase Inhibitors: Progress and Therapeutic Potential
5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.
research Clinical Use of 5α-Reductase Inhibitors
Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
research Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia
Finasteride effectively treats male hair loss, improving growth and density.
research 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia
Finasteride improves hair growth in men with androgenetic alopecia.
research Clinical Application of 5α-Reductase Inhibitors
5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.
research Hair Growth and Rejuvenation: An Overview
The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.
research Hemodynamic Effects of Minoxidil Following Intravenous Infusions in Untreated Hypertensive Patients
Minoxidil given intravenously caused small changes in diastolic blood pressure and increased heart rate at higher concentrations in patients with high blood pressure.
research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances
Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.
research Clinical Biochemistry of Dihydrotestosterone
Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
research Endocrine Control of Benign Prostatic Hyperplasia
Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.
research The Development of BRL 7660 as an Anti-Acne Agent
BRL 7660, once studied for male contraception, showed promise as an acne treatment but was not developed further due to competing drugs.
research Medical Treatments for Male and Female Pattern Hair Loss
Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.
research Non-Polycystic Ovary Syndrome–Related Endocrine Disorders Associated with Hirsutism
Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.
research Repurposing Steroidogenesis Inhibitors for the Therapy of Neuropsychiatric Disorders: Promises and Caveats
Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.
research Hirsutism: From Diagnosis to Use of Antiandrogens
Antiandrogens are the main treatment for hirsutism, with individualized care and safe, affordable options needed.
research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex
An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.
research Inhibition of Lipogenesis and Sebum Secretion for Lotus Corniculatus Seed Extract In Vitro and In Vivo
Lotus corniculatus seed extract reduces oily skin by decreasing sebum production.
research Androgens Activate Lipogenesis Through an AKT-Independent mTOR Pathway Stimulation and a Limitation of Autophagy in an Androgen-Sensitive Sebocyte Cell Line
Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial
Testosterone increases muscle mass regardless of DHT conversion blocking.
research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ
Sex hormones, especially androgens, play a key role in causing acne.
research Expression of Steroidogenic Enzymes in Human Sebaceous Glands
Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.
research Antiandrogens and the Skin
Antiandrogens can treat acne, hirsutism, and seborrhea by reducing sebum production and androgen action.
research Impact of Testosterone on Hair and Skin
Testosterone can cause acne and male-pattern baldness, affects hair growth in men and women, and makes male skin more sensitive.
research Assessment of Efficacy and Safety of Dapsone Gel 5% in the Treatment of Acne Vulgaris
Dapsone gel 5% is effective and safe for treating acne.
research Establishment and Characterization of Human Sebocytic Progenitor Cells That Can Differentiate Into Functional Sebocytes
Researchers created human cells that can turn into sebocytes, which may help study and treat skin conditions like acne.
research Saw Palmetto Extract: A Dermatologist's Perspective
Saw palmetto extract may help with hair loss and acne but needs more research on safety and long-term effects.
research Finasteride in Androgenetic Alopecia in Men
Finasteride is effective in stopping hair loss and promoting regrowth in most men with mild side effects.