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The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Saw palmetto is an effective natural treatment for hair loss with minimal side effects.

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

New treatments for male hypogonadism are effective and should be personalized.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Minoxidil and caffeine in transfersomes improve hair growth treatment.

Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

5-Alpha Reductase Inhibitors are effective for male hair loss and some skin conditions, but their effectiveness in women and safety concerns require careful use.

The document explains various skin conditions and their treatments.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

Androgens prevent hair growth by changing Wnt signals in cells.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

DA-9401 helps protect rat testis from finasteride damage.

Finasteride works better for hair loss in patients 26 or younger.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

A mix of Panax ginseng and bee-pollen may help prevent prostate enlargement in rats.