Androgen Action and 3D Culture Conditions Influence Dermal Papilla Cells' Inductive Properties: The Role of Wnt Agonists/Antagonists Balance
August 2016
in “
Journal of Investigative Dermatology
”
dihydrotestosterone DHT Wnt signaling dermal papilla cells DPCs hair follicle stem cell differentiation HFSC differentiation Wnt agonists Wnt 5a Wnt 10b Wnt antagonist DKK-1 androgenetic alopecia 3D culture conditions DPC-spheroids Wnt pathway hair follicle stem cells HFSCs Wnt proteins androgenic alopecia
Studysummary This study found that dihydrotestosterone alters the balance of Wnt pathway regulators in dermal papilla cells, hindering hair follicle stem cell differentiation and contributing to hair follicle miniaturization.
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