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    Glossary Dermal Sheath Cup Cells

    specialized cells supporting hair follicle growth and regeneration

    Dermal Sheath Cup Cells are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling to the surrounding follicular cells, which helps in the cycling and maintenance of hair.

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    Research 30 of 1000+

    1. Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study Journal of The American Academy of Dermatology · 2020 · 22 citations
    2. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells Experimental Dermatology · 2023
    3. High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss Journal of Dermatological Science · 2023
    4. Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study The Journal of Dermatology · 2023
    5. 602 Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study Journal of Investigative Dermatology · 2023
    6. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    7. Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases Stem Cell Research & Therapy · 2025
    8. 281 Phase I/IIa clinical trial for the treatment of androgenetic alopecia using intradermal injections of cultured autologous dermal sheath cup cells Journal of Investigative Dermatology · 2017
    9. Correction to “Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single‐Arm, Multi‐Center, Phase III Equivalent Clinical Study” The Journal of Dermatology · 2026
    10. Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup International Journal of Molecular Sciences · 2024
    11. Microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering Acta Biomaterialia · 2022 · 45 citations
    12. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    13. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    14. Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin Biochemical and Biophysical Research Communications · 2019 · 40 citations
    15. Effective and economical cell therapy for hair regeneration Biomedicine & Pharmacotherapy · 2022 · 17 citations
    16. Cell-based treatments for hair loss: research update on “hair cloning” Hair transplant forum international · 2013 · 2 citations
    17. Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street? Journal of Investigative Dermatology · 2003 · 47 citations
    18. Alteration of Skin Properties with Autologous Dermal Fibroblasts International Journal of Molecular Sciences · 2014 · 67 citations
    19. Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.) Elsevier eBooks · 2017 · 1 citations
    20. 282 WITHDRAWN Journal of Investigative Dermatology · 2017
    21. Mendeley Supplemental Document 1 2020
    22. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    23. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014 · 184 citations
    24. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022 · 37 citations
    25. Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells Development · 1996 · 61 citations
    26. Dermal Sheath Cells and Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    27. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    28. Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis Preprints.org · 2024 · 1 citations
    29. Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation Biomedicines · 2022 · 7 citations
    30. 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging Journal of Investigative Dermatology · 2017