Hair Regeneration and Rejuvenation: Pipeline of Medical and Technical Strategies

    January 2022 in “ Stem cell biology and regenerative medicine ”
    Summik Limbu, Paul Kemp
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    TLDR New treatments are needed for hair loss, and cell therapies might reverse hair thinning.
    The document reviews the development of medical and technical strategies for treating androgenetic alopecia, a prevalent type of hair loss. It notes that while adult mouse dermal follicular cells have shown the ability to generate new hair, no cell therapy for this condition is currently available in the market. The potential of hair follicle dermal papilla and dermal sheath cells to create new hair follicles is highlighted. However, early 2000s clinical trials by Intercytex and Aderans Research Institute, while showing some hair neogenesis, did not meet expected cosmetic efficacy. The current focus is on rejuvenating existing, miniaturising hair follicles rather than regenerating them. The document concludes that alternative treatments for androgenetic alopecia are needed, and cell therapies using dermal papilla and dermal sheath cells could potentially reverse hair follicle miniaturisation.
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      community The MPB itch aka DHT itch is very real.

      in Chat  9 upvotes 1 year ago
      Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

      community This serum outperformed Minoxidil in a recent study. Please debunk

       23 upvotes 5 years ago
      A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

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      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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