Efficacy of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Single Arm, Multi-Center, Confirmatory Clinical Study

April 2023 in “ Journal of Investigative Dermatology ”

K. Harada, M. Ohyama, S. Niiyama, R. Irisawa, K. Mae, M. Mori, H. Wakimoto, M. Kinoshita-Ise, M. Fukuyama, R. Hayakawa, M. Takagi, M. Yamazaki, M. Miyoshi, S. Nishikawa, S. Sato, Y. Nakazawa, T. Sugimoto, M. Ogo, R. Tsuboi

autologous cell-based therapy dermal sheath cup cells DSCC pattern hair loss PHL global photography phototrichogram terminal hair ratio cell-based therapy DSCC injections hair loss hair diameter hair cross-sectional area

TLDR Autologous cell-based therapy using dermal sheath cup cells may help treat pattern hair loss, especially in women.

A confirmatory clinical study investigated the efficacy of autologous cell-based therapy using dermal sheath cup cells (DSCCs) for treating male and female pattern hair loss (PHL). The study involved 18 males and 19 females aged 20 to 59 years, who received DSCC injections twice at a 3-month interval. Efficacy was evaluated over 12 months using global photography and phototrichogram. Results showed that 29.2% of subjects experienced improvement, with cumulative hair diameter and hair cross-sectional area increasing by 2.3% and 4.3%, respectively. Female gender and a high terminal hair ratio were linked to better outcomes. No serious adverse events were reported, suggesting that this therapy could be a promising option for PHL, particularly in women.

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