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Rice bran extract caused moderate skin irritation but no eye irritation, while a diluted essence was not irritating to skin and only slightly to guinea pigs.

Exposure to Corexit dispersants during the oil spill cleanup was linked to increased respiratory and eye irritation symptoms in workers.

The 3:2 combination of pandan and snake plant extracts promotes hair growth effectively and is safe to use.

The HG3 hair gel is the most effective for treating seborrheic dermatitis.

Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.

Researchers developed a 3D model of human hair follicle cells that can help understand hair growth and test new hair loss treatments.

The hair tonic with cinnamon oil and coconut oil was stable and caused very mild irritation.

St. John's Wort extract and oil safety in cosmetics is unclear; more data needed on photosensitization, toxicity, and human irritation.

Different oil products cause varying levels of skin irritation in mice, which could potentially lead to tumors.

Nanoemulgel improves hair growth and quality using finasteride without irritation.

Cinchonine Nanostructured Lipid Carriers serum safely and effectively stimulates hair growth and increases the number and size of hair follicles.

Procyanidin B-2 is safe to use on skin as a hair growth product.

Topical Valproate is safe for human skin and unlikely to cause irritation.

Fullerenes show potential in skin care but need more safety research.

No treatments fully cure or prevent alopecia areata; some help but have side effects or need more research.

Niosomes are the most effective at delivering drugs to the skin with minimal absorption into the body.

The hair tonic from Usada Bali plants increased hair growth without irritating the skin.

Red pigmented rice, like Sang-Yod rice, could help promote hair growth and prevent hair loss.

P-SLN nanoparticles effectively deliver podophyllotoxin to the skin.

Finasteride-loaded nanogels are effective, safe, and improve drug absorption through the skin.

Herbal extract improves hair growth in female pattern baldness.

Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.

Rabbit skin with active hair growth shows thicker, redder areas due to larger, more numerous hair follicles and increased blood vessels.

Black seed oil significantly protects against hair loss from chemotherapy.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Alopecia Areata is an autoimmune condition often starting before age 20, with varied treatment success and a need for personalized treatment plans.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

Bee venom might be a good alternative treatment for various skin conditions because it has many healing properties.

Ketoconazole cream is effective for skin conditions like seborrheic dermatitis and may help with hair loss and other skin issues, with generally mild side effects.

Herbal nano-formulations show potential for effective skin delivery but need more research.