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In this study, researchers found that androgen receptor expression and AKR1C-mediated androgen inactivation, including AKR1C4, are prominent in scalp sebaceous glands, with AKR1C expression decreasing with age and differing by sex, suggesting these changes may impact hair follicle health as people age.

In this study, high-dose Arachis hypogaea root extract significantly reduced prostate weight and markers of glandular hyperplasia in testosterone-induced BPH in mice, with associated changes in inflammatory gene expression and beneficial shifts in gut microbiota.

This study found that, although finasteride reduced dihydrotestosterone levels in males with heavy episodic drinking, it did not significantly alter brain activation or craving but was linked to a stronger desire not to drink.

In this study, high-resolution ultrasound imaging revealed that DHT administration in male C57BL/6 mice leads to increased epidermal and dermal thicknesses and decreased skin elasticity, simulating structural changes associated with Androgenetic Alopecia.

This study reported high analytical performance of an RMP for DHT quantification, with the ability to differentiate between 5α-DHT and 5β-DHT isomers, making it suitable for routine assay standardization and clinical sample evaluation.

In this study, network meta-analyses were used to explore the ranking of various 5-alpha reductase inhibitor regimens on reducing dihydrotestosterone levels and to investigate whether this reduction correlates with increased total hair density in male androgenetic alopecia.

This study found that androgenetic alopecia in men is associated with significant psychological distress and moderate depression, suggesting a possible link between raised dihydrotestosterone levels and mental health issues.

This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.

This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients.

This study suggests that Terminalia chebula fruit extract may promote hair growth in androgenetic alopecia by activating specific signaling pathways and inhibiting 5α-reductase, showing effectiveness comparable to finasteride.

This study found that women with polycystic ovary syndrome had significantly higher serum dihydrotestosterone levels than healthy controls, supporting its use as a reliable biomarker for early detection of the condition.

In this study, hemp seed-derived exosomes (E40) showed potential for counteracting DHT-induced inhibition of feather follicle development in chicken embryos by modulating critical signaling pathways, suggesting a therapeutic approach for alopecia.

In AGA animal models, this study found that finasteride-loaded microspheres provided rapid and sustained dihydrotestosterone suppression, promoting hair regrowth through dual-phase drug release.

This study found that sulforaphane-rich broccoli sprout extract significantly accelerated hair regrowth in a mouse model of androgenetic alopecia, suggesting its potential as a safe and effective natural therapy.

UVA exposure worsens hair loss by activating a specific cell pathway.

This study found that administering adipose-derived stem cells with ATP improved hair regrowth in male mice with androgenetic alopecia, while the combination was less effective in female mice.

In this study, exosomes derived from Iris germanica L. rhizomes (Iris-exosomes) were reported to alleviate oxidative stress and improve mitochondrial function in human follicle dermal papilla cells by activating the Wnt/β-catenin signaling pathway, suggesting potential benefits for hair loss treatment.

In this chicken embryo study, E40 hemp seed callus-derived exosomes counteracted DHT-induced inhibition of hair follicle development, suggesting potential for alopecia treatment and hair follicle regeneration.

This study found that the combination of finasteride and black soybean extract showed synergistic protective effects against DHT-induced damage in hair follicle cells, suggesting potential benefits for treating androgenetic alopecia.

This study reported that female patients aged 20-30 with androgenetic alopecia had higher serum DHT levels compared to healthy individuals, and those with a family history of the condition experienced earlier onset than those without it.

In this study, researchers observed that red and red-orange LED light therapy stimulates nitric oxide production and decreases dihydrotestosterone synthesis in cell models, suggesting a potential mechanism for using light therapy to treat androgenetic alopecia.

This study demonstrated that ellagic acid promoted hair regrowth in a DHT-induced androgenic alopecia mouse model by inhibiting ferroptosis through the activation of the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for androgenic alopecia.

This study found that sleep deprivation in mice can trigger prostatitis by activating the cGAS-STING pathway due to reduced levels of dihydrotestosterone and melatonin, resulting in a pro-inflammatory environment, while recovery sleep can mitigate these effects.

This animal study observed that dihydrotestosterone increased arterial stiffness and decreased estrogen receptor expression in female mice, potentially impacting cardiovascular health in contexts of androgen use.

This study found that 12.5% moringa seed oil demonstrated optimal anti-alopecia activity in rabbits, significantly improving hair weight compared to the treatment with 0.1% finasteride.

This study reported no association between higher serum testosterone or dihydrotestosterone levels and the incidence or progression of lower urinary tract symptoms in asymptomatic or symptomatic men in the REDUCE trial, challenging the belief that elevated androgens contribute to these symptoms.

This case report describes a unique instance where elevated prolactin levels from a pituitary adenoma were associated with hirsutism due to increased dihydrotestosterone, with treatment leading to normalization.

This study using human and animal models found that adipose-derived stem cell exosomes promoted hair growth and counteracted dihydrotestosterone's inhibitory effects, suggesting potential therapeutic applications for androgenetic alopecia.

This study observed that both finasteride and dutasteride significantly decreased dihydrotestosterone concentrations in hair, with dutasteride showing the greatest reduction.

This study found that testosterone contributed to increased arterial stiffness and cardiovascular damage in female mice, linked with decreased estrogen receptor expression, and suggests implications for women with polycystic ovarian syndrome or those taking testosterone.