An Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry-Based Candidate Reference Measurement Procedure for the Quantification of 5-Alpha-Dihydrotestosterone in Human Serum and Plasma

    January 2026 in “ Clinical Chemistry and Laboratory Medicine (CCLM) ”
    L.L. Lewin, Michael Stadlmeier, Neeraj Singh, Friederike Bauland, Daniel Köppl, Alexander Gaudl, Andrea Geistanger, Uta Ceglarek, Manfred Rauh, Judith Taibon
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    Studysummary This study reported high analytical performance of an RMP for DHT quantification, with the ability to differentiate between 5α-DHT and 5β-DHT isomers, making it suitable for routine assay standardization and clinical sample evaluation. Our plain-language summary of this paper — not a Tressless recommendation.
    The study presents a reference measurement procedure (RMP) using isotope dilution-liquid chromatography-tandem mass spectrometry for quantifying 5-alpha-dihydrotestosterone (DHT) in human serum and plasma. The RMP demonstrated high analytical performance and met the necessary requirements for measurement uncertainty. It effectively differentiated between the 5α-DHT and 5β-DHT isomers, making it suitable for routine assay standardization and clinical sample evaluation.
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