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    Glossary Dihydrotestosterone

    potent androgen hormone derived from testosterone

    Dihydrotestosterone (DHT) is a potent androgen hormone derived from testosterone through the action of the enzyme 5-alpha-reductase. It plays a crucial role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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    1. Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone Chemistry Central Journal · 2013 · 8 citations
    2. Re: The Efficacy of Dihydrotestosterone Transdermal Gel Before Primary Hypospadias Surgery: A Prospective, Controlled, Randomized Study The Journal of Urology · 2008 · 1 citations
    3. Testosterone and dihydrotestosterone production in genetically furless and furred male rabbits and effects on growth. Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008 · 2008 · 1 citations
    4. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    5. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    6. Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia European Urology · 2000 · 184 citations
    7. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011 · 173 citations
    8. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    9. The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study 2002 · 110 citations
    10. Testosterone, Dihydrotestosterone, and Incident Cardiovascular Disease and Mortality in the Cardiovascular Health Study 2014 · 104 citations
    11. A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride Clinical Pharmacology & Therapeutics · 1998 · 60 citations
    12. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    13. The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications The Prostate · 1986 · 57 citations
    14. Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts* 1983 · 57 citations
    15. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone American Journal of Physiology-Endocrinology and Metabolism · 2014 · 53 citations
    16. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5<i>α</i>-Reductase: Definition of a Selective Role for Dihydrotestosterone* Endocrinology · 1986 · 53 citations
    17. SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism Viruses · 2021 · 50 citations
    18. Clinical biochemistry of dihydrotestosterone Annals of Clinical Biochemistry · 2013 · 50 citations
    19. Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia Food and chemical toxicology · 2012 · 44 citations
    20. Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015 · 42 citations
    21. MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen<sup>1</sup> The Journal of Clinical Endocrinology & Metabolism · 1997 · 37 citations
    22. Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line Journal of Investigative Dermatology · 2009 · 36 citations
    23. Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia Postepy Dermatologii I Alergologii · 2014 · 35 citations
    24. Morphology of the testis and the epididymis in rats with dihydrotestosterone (DHT) deficiency. PubMed · 2004 · 34 citations
    25. Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae Growth Hormone & IGF Research · 2024 · 32 citations
    26. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes Archives of Dermatological Research · 2009 · 32 citations
    27. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 31 citations
    28. Clinical relevance of testosterone and dihydrotestosterone metabolism in women ˜The œAmerican journal of medicine · 1995 · 31 citations
    29. Prevention and treatment of experimental prostate cancer in lobund-wistar rats. I. Effects of estradiol, dihydrotestosterone, and castration 1989 · 31 citations
    30. A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors Medical Hypotheses · 2017 · 30 citations