December 2024 in “Journal of Health and Beauty” This study found that the Dongeui Hot Spring Water complex (Dongui Hot Spring Water CPX), containing sea slug extract and panthenol, demonstrated higher antioxidant activity and cell proliferation, suggesting potential benefits for preventing hair loss and improving scalp health.
July 2021 in “Clinical case reports and studies” In this case report, a 9-year-old boy with diffuse alopecia areata showed improvement with topical diphencyprone immunotherapy, suggesting it as a safe and effective treatment option in pediatric cases of alopecia areata resistant to other therapies.
December 2024 in “Journal of Health and Beauty” In laboratory conditions, this study found that the Dongeui Hot Spring Water Complex, containing sea slug extract, demonstrated enhanced antioxidant activity and promoted hair papilla cell proliferation compared to a control, suggesting potential benefits for scalp health and hair loss prevention.
710 citations
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May 2023 in “European Urology” This study highlights that improved diagnostic techniques for prostate cancer could decrease the number of men needing diagnosis and treatment to save one life and identifies avoidable risk factors, such as smoking, diet, and occupation, that may influence prostate cancer risk.
January 2025 in “JCEM Case Reports” This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.
November 2008 in “Journal of the American Academy of Dermatology”
3 citations
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January 2018 in “PeerJ” This study successfully optimized a culture strategy for dermal papilla cells and established an immortalized cell strain, iDP6, which is suitable for research and application.
September 2024 in “Journal of the American Academy of Dermatology” Alopecia areata often recurs after treatment with diphenylcyclopropenone.
3 citations
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April 2024 in “JAAD Case Reports” This article reviews DPCP's use as a topical immunotherapy for alopecia areata and discusses its suggested mechanism, but reports no clinical results.
36 citations
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May 2005 in “BMC dermatology” This study found that topical diphenylcyclopropenone was effective in treating severe alopecia areata but had a high relapse rate and was often accompanied by side effects like eczema and lymphadenopathy.
March 2005 in “Journal of The American Academy of Dermatology” Diphencyprone treatment protocols could be simplified as no harm occurred despite not fully following them.
16 citations
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April 2000 in “Contact dermatitis” In this report, a 19-year-old Japanese man experienced severe and prolonged urticarial reactions following treatment with diphenylcyclopropenone for alopecia universalis, emphasizing the need for caution with potent sensitizers.
January 2017 in “프로그램북(구 초록집)”
This study successfully optimized a culture strategy for dermal papilla cells and established an immortalized cell strain, iDP6, which closely resembles primary DP cells in key characteristics.
June 2023 in “International Journal of Clinical Research and Reports” This study found that higher concentrations of topical diphenylcyclopropenone, especially when prepared with acetone, showed better stability over 6 months compared to lower concentrations.
17 citations
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October 2011 in “International Journal of Immunopathology and Pharmacology” This study found that after 24 weeks of DPCP treatment for alopecia areata, there was a significant increase in new capillaries and hair regrowth detectable by videocapillaroscopy.
1 citations
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February 2023 in “Deleted Journal” This study found that Diphenylcyclopropenone (DCP) was effective for treating extensive alopecia areata in Thai patients, although a high relapse rate suggests maintenance therapy might be necessary.
May 2024 in “Journal of the Egyptian Womenʼs Dermatologic Society” This study suggests that DPCP treatment can be effective and safe for severe alopecia areata in children, with maintenance therapy potentially reducing relapse rates.
18 citations
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January 2010 in “Dermatology Research and Practice” This case report describes a 30-year-old Brazilian male who developed vitiligo lesions following diphencyprone therapy for alopecia areata.
14 citations
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July 2021 in “Journal of the American Academy of Dermatology” Topical dapsone gel reduced flare-ups in folliculitis decalvans without side effects.
8 citations
,
January 2021 in “Journal of Pharmaceutical Investigation” 10 citations
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June 2019 in “Dermatologic therapy” In this study, treatment with DPCP alone was more effective for hair regrowth and presented fewer side effects in chronic extensive alopecia areata compared to combination therapy with DPCP and anthralin.
March 1998 in “Journal of dermatological science” Diphencyprone initially increases mouse hair growth, then slows it, possibly due to changes in specific protein levels.
10 citations
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January 2018 in “Postępy Dermatologii i Alergologii” This study found that 21 out of 39 patients with alopecia areata experienced more than 50% hair regrowth after six months of DPCP treatment, with better outcomes observed in those treated at 3-week intervals compared to weekly intervals.
July 2026 in “Journal of the American Academy of Dermatology”
1 citations
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February 2004 in “Dermatologic Surgery” This study found that using deep plane fixation during scalp surgeries significantly reduced closure tension and allowed for increased tissue excision compared to standard techniques without fixation.
55 citations
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January 1988 in “Dermatology” This study observed that 6.7% of patients treated with diphencyprone for alopecia areata developed vitiligo, with varying patterns and improvements noted among cases.
July 2025 in “Journal of Investigative Dermatology” Hhip-Cre effectively targets dermal papilla cells for gene manipulation in hair biology.
1 citations
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August 2024 in “Journal of Pharmacy & Pharmaceutical Sciences” This study found that forming inclusion complexes of DPCP with HPβCD using the 3D ground mixture method enhances its anti-inflammatory activity at lower doses compared to complexes with β-CD.
5 citations
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January 2014 in “Hospital pharmacy” This case report suggests that frequent application of diphenylcyclopropenone 2% solution to the scalp for alopecia areata may lead to scalp angioedema.