Severe Dermographism After Topical Therapy With Diphenylcyclopropenone for Alopecia Universalis

April 2000 in “ Contact dermatitis ”

Natalja Skrebova, Yumiko Nameda, Hirotsugu Takiwaki, Seiji Arase

alopecia universalis diphenylcyclopropenone contact dermatitis dermographism urticarial response erythematous reactions sensitizers DPCP

TLDR A man developed severe skin reactions after using a treatment for hair loss.

A 19-year-old Japanese man with an 11-year history of alopecia universalis developed acute contact dermatitis and severe dermographism after the first application of a 0.003% diphenylcyclopropenone (DPCP) solution. Despite significant improvement in urticarial response over 3 months, erythematous reactions persisted. This case highlighted the need for caution when using potent sensitizers like DPCP in treatment.

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