205 citations,
April 2005 in “Journal of Investigative Dermatology” Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.
Current hair regeneration methods show promise but face challenges in maintaining cell effectiveness and creating the right environment for hair growth.
4 citations,
August 2005 in “Archives of Dermatological Research” Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
240 citations,
April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
25 citations,
April 2015 in “Journal of Investigative Dermatology” GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
7 citations,
January 2016 in “Methods in molecular biology” Mouse hair follicle stem cells were successfully isolated and used to regenerate hair follicles with two different methods.
159 citations,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
3 citations,
January 2021 in “Plastic and Aesthetic Research” Hair loss reduces hair thickness and coverage, but drug treatments mainly revive dormant hairs rather than reverse thinning; patients often undervalue their hair loss severity.
32 citations,
April 2016 in “Journal of Investigative Dermatology” STAT5 activation is crucial for starting the hair growth phase.
22 citations,
February 2002 in “Journal of theoretical biology” The model showed that randomness accurately describes individual hair growth cycles and that synchronization can cause large fluctuations not seen in humans.
51 citations,
January 2003 in “Hormone Research in Paediatrics” Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
47 citations,
May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.
65 citations,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
17 citations,
June 2017 in “British Journal of Dermatology” The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.
125 citations,
September 2001 in “The FASEB Journal” Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.
75 citations,
August 2011 in “Journal of Investigative Dermatology” Forming spheres boosts the ability of certain human cells to create hair follicles when mixed with mouse skin cells.
49 citations,
September 2007 in “Journal of Investigative Dermatology” The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.
11 citations,
July 2017 in “Regenerative Medicine” The patch assay can create mature hair follicles from human cells and may help in hair loss treatments.
300 citations,
August 2012 in “Seminars in Cell & Developmental Biology” The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
66 citations,
June 2010 in “Experimental Dermatology” The hair follicle is a great model for research to improve hair growth treatments.
48 citations,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.
5 citations,
July 2018 in “Experimental Dermatology” The "Punch Assay" can regenerate hair follicles efficiently in mice and has potential for human hair regeneration.
January 2015 in “Journal of clinical & experimental dermatology research” A protein combining parathyroid hormone and collagen helped hair regrow in mice with a hair loss condition.
Hair follicles can be used to quickly assess drug effects in cancer treatment.
42 citations,
January 2014 in “Cold Spring Harbor Perspectives in Medicine” Hair growth is influenced by various body and external factors, and neighboring hairs communicate to synchronize regeneration.
2 citations,
July 2020 in “Electromagnetic Biology and Medicine” Low-frequency electromagnetic fields help regenerate hair follicles using a mix of skin cells.
10 citations,
November 2010 in “Pigment Cell & Melanoma Research” Only skin melanocytes, not other types, can color hair in mice.