6 citations
,
December 2017 in “Molecular Medicine Reports” This study found that Wnt5a expression may suppress cell differentiation and induce an inflammatory response in HaCaT keratinocytes, which could be relevant to psoriasis development.
6 citations
,
April 2017 in “Experimental dermatology” This study found that B6.CD80CD86−/− mice developed autoimmune-like alopecia with nearly 100% incidence by 40 weeks, making them a promising model for studying human alopecia areata.
6 citations
,
January 2016 in “Journal of Stem Cell Research & Therapy” This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.
5 citations
,
January 2022 in “PloS one” This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.
5 citations
,
July 2021 in “Basic & Clinical Pharmacology & Toxicology” This study found that nicotine caused damage to cochlear hair cells in vitro, and melatonin might protect against this damage, indicating its potential as a treatment for smoking-induced hearing loss.
5 citations
,
November 2020 in “Cells” The researchers reported that using a concentrate of conditioned mesenchymal stem cells derived from the placenta accelerated wound healing and regeneration in laboratory animals with severe local radiation injuries.
5 citations
,
December 2017 in “Tissue and cell/Tissue & cell” This study observed that skin stem cells in dogs could be identified using CD34 and CD200 markers, although further refinement in isolation and cultivation methods is needed for better identification.
5 citations
,
November 2017 in “Asian Journal of Beauty and Cosmetology” This study found that sinapic acid demonstrated antioxidant and anti-inflammatory effects against UVB-induced damage in human keratinocytes, suggesting its potential as an anti-aging cosmetic ingredient.
5 citations
,
August 2013 in “InTech eBooks” This article reviews the role of KLF4, a transcription factor, in various cellular processes and its dual function as a tumor suppressor or oncogene depending on the context, but presents no new experimental results.
4 citations
,
July 2025 in “Frontiers in Immunology” This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
4 citations
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May 2025 in “npj Parkinson s Disease” This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms.
4 citations
,
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.
4 citations
,
September 2020 in “Annals of Translational Medicine” This study found that concentrated nanofat, used alone or with decellularized nanofat, may enhance hair growth in mice by activating dermal papilla cells and the anagen phase.
4 citations
,
July 2020 in “International Journal of Cosmetic Science” This study found that while all hair removal techniques increased axillary erythema and skin dryness, shaving caused less erythema but more dryness than plucking or waxing, without affecting post-inflammatory hyperpigmentation or other skin properties.
4 citations
,
January 2020 in “Cells” This study found that the transcriptome of skin stem cells in mice changes significantly with age, revealing specific age-dependent biological programs and transcriptional hubs.
4 citations
,
January 2004 in “Biological and Pharmaceutical Bulletin” In this study, AgK114 was found to be transiently induced in hamster epidermal keratinocytes following skin damage, suggesting its role in the recovery process after injury.
3 citations
,
May 2025 in “Cell Death and Disease” This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.
3 citations
,
May 2022 in “Oncogene” This study revealed that Vav2 and Vav3 play roles in regulating hair follicle bulge stem cells in normal conditions and cancer stem cell activation and remodeling in mice.
3 citations
,
September 2020 This study found that the medication dyclonine has a potent inhibitory effect on the TRPV3 channel, effectively rescuing cell death and alleviating pruritus symptoms in a mouse model with gain-of-function TRPV3 mutations, suggesting potential for treating skin inflammation.
3 citations
,
January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu” This study reported that knocking out the HR gene in pigs using CRISPR/Cas9 led to hairless eyelids and abnormalities in the thymus and peripheral blood, suggesting pigs as a model for human HR-related hair disorders.
3 citations
,
January 2003 in “Cell Structure and Function” This study found that Meth-A cells induced alopecia in mice, but this effect was blocked by a protein kinase inhibitor, suggesting immunological mechanisms involving lymphokine-activated killer cells.
2 citations
,
December 2025 in “Nature Communications” This study found that the repressive histone mark H2AK119ub links inhibitory FGF signals with the quiescent state in hair follicle stem cells, revealing a signaling-epigenetic axis crucial for maintaining stem cell quiescence and tissue homeostasis.
2 citations
,
August 2023 in “Journal of Endocrinological Investigation” In this study, researchers found that pregnant mice exposed to excessive androgen led to thinner ventricular walls and cardiac hypertrophy in offspring, suggesting that prenatal androgen exposure adversely affects cardiac health through reduced cardiomyocyte proliferation.
2 citations
,
May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.
2 citations
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January 2023 in “Bioresource Technology Reports” This study suggests that using glycosidases to lyse the polysaccharides of Botryoccocus braunii may allow for the semi-continuous recovery of hydrocarbons while keeping the cells viable.
2 citations
,
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, overexpression of miR-29 in mice led to aging-related phenotypes and early lethality, demonstrating its significant role in driving aging processes.
2 citations
,
September 2018 in “Tissue Engineering Part A” This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.
2 citations
,
December 2016 in “Experimental cell research” This study reveals that CSPG4-positive basal cell keratinocytes show distinct global gene expression from CSPG4-negative cells, despite similar colony-forming efficiency.
2 citations
,
October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.