Autoimmune Hair Loss Induced by Alloantigen in C57BL/6 Mice

    January 2003 in “ Cell Structure and Function ”
    Zhi-ping Zong, Shinobu Matsui, Aili Li, Shogo Katsuda, Nobuo Yamaguchi
    Image of study
    TLDR Injecting certain cells into mice caused hair loss, which was preventable with a specific inhibitor.
    The study demonstrated that injecting Meth-A cells expressing H-2K(d).D (d) antigen into C57BL/6 mice, which express H-2K(b).D (b) antigen, induced alopecia, characterized by dense mononuclear cell infiltration and foreign-body giant-cell reactions in hair follicles. This effect was inhibited by K252a, a protein kinase inhibitor. Lymphocytes from Meth-A cell-injected mice showed significant differences compared to normal mice, and when these lymphocytes were cultured and transferred to normal mice, they also induced alopecia. The findings suggested that the alloantigen disturbed immunological homeostasis, with lymphokine-activated killer cells playing a crucial role in the autoimmune response against hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 282 results

      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  132 upvotes 11 months ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

      community I have a theory about hair loss

      in Treatment 3 weeks ago
      Hair loss is often linked to inflammation and DHT, with treatments like finasteride, dutasteride, and minoxidil being effective for many. Natural remedies like turmeric and oils are discussed, but medications are generally seen as more reliable for managing genetic hair loss.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  97 upvotes 11 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 10 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

    Similar Research

    5 / 1000+ results