Pink1 Deficiency Rewires Early Immune Responses in a Mouse Model of Parkinson’s Disease Triggered by Intestinal Infection

    May 2025 in “ npj Parkinson s Disease ”
    Sherilyn Junelle Recinto, Alexandra Kazanova, Lin Liu, Brendan Cordeiro, Shobina Premachandran, Hicham Bessaiah, Alexis Allot, Elia Afanasiev, Shinjini Mukherjee, Jessica Pei, Adam MacDonald, Moein Yaqubi, Heidi M. McBride, Diana Matheoud, Louis‐Éric Trudeau, Samantha Gruenheid, Jo Anne Stratton
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    Studysummary This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigates the role of PINK1 deficiency in early immune responses in a mouse model of Parkinson's disease (PD) triggered by intestinal infection. The researchers used PINK1 knockout mice, which exhibit PD-like motor symptoms, to map immune events at the infection site. Single-cell RNA sequencing revealed that peripheral myeloid cells are the first to show significant dysregulation, followed by an abnormal T cell response. The study found that these myeloid cells have an increased tendency for antigen presentation and develop a proinflammatory profile that can induce cytotoxic T cell responses. The findings suggest that PINK1 is crucial in regulating gut immune functions, contributing to early PD-related disease mechanisms.
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