November 2018 in “Annals of oncology” This study found that the computer-controlled RV-01 scalp cooling device helped prevent significant hair loss in metastatic breast cancer patients treated with eribulin, with none of the 16 patients requiring a wig and experiencing minimal discomfort.
This study found that liquid nitrogen cryotherapy significantly improved alopecia areata in 27.4% of treated patients after six weeks, with no association between treatment efficacy and factors like age or gender.
57 citations
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December 2011 in “Lasers in Surgery and Medicine” This study suggests that selective photothermolysis of sebaceous glands using free electron laser pulses may offer a novel approach to treating acne by causing targeted thermal damage without affecting the epidermis.
February 2009 in “Journal of The American Academy of Dermatology” This study found that fractional infrared technology may improve skin laxity and thickness in the cervical area without side effects in a small group of patients.
15 citations
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October 2006 in “Journal of the American Academy of Dermatology” This case report describes subcutaneous emphysema in a patient's forearm as a rare complication of liquid nitrogen spray used on hypertrophic actinic keratosis, resolving spontaneously within a day.
January 2024 in “RSC pharmaceutics” This source discusses using stratum corneum ablation as a promising method to enhance transdermal drug delivery by temporarily removing the skin's outermost barrier to improve medication absorption.
21 citations
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September 2016 in “Breast” This study investigated scalp cooling in breast cancer patients undergoing chemotherapy, finding that those who reached a lower mean scalp skin temperature of 18 °C during cooling were less likely to require a wig or head covering compared to those with higher temperatures.
1 citations
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June 2023 in “Sciential - McMaster Undergraduate Science Journal” This paper reviews scalp cooling as an effective method for preventing chemotherapy-induced alopecia, highlighting recent trials that demonstrate its ability to preserve and regrow hair, thus improving patient well-being.
15 citations
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February 2013 in “Journal of Clinical Medicine and Research” The researchers reported that both cryotherapy and betamethasone lotion yielded similar improvement rates for alopecia areata patches, without complete recovery observed in any patient.
July 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, the researchers found that cryopreserving nanofat at -20°C maintained its viability and regenerative potential, comparable to freshly generated nanofat, supporting its potential for repeated use in regenerative applications.
March 2026 in “Scientific Reports” This study found that scalp cooling significantly improved hair preservation and reduced psychological distress in gynecologic cancer patients undergoing chemotherapy compared to usual care.
19 citations
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August 2007 in “Seminars in Plastic Surgery” This review discusses five popular resurfacing technologies for facial rejuvenation, highlighting their role in achieving smoother, healthier, and younger-looking skin, and reports no new clinical results.
January 2025 in “Ros Dok Rostocker Dokumentenserver (Universitätsbibliothek Rostock)” This pilot study reported that cold atmospheric plasma treatment significantly reduced inflammatory lesions and erythema in rosacea patients, also improving their quality of life.
9 citations
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November 2022 in “Journal of Cosmetic Dermatology” Among patients treated at Thomas Jefferson University, this study found that adding cryotherapy to intralesional triamcinolone acetonide (IL TAC) was more effective at reducing keloid size compared to IL TAC alone, although both treatments similarly eased pruritus and pain.
March 2025 in “Tissue and Cell” In this study, cryopreserved fibroblast cell sheets cultured on a new substrate showed significantly enhanced healing of cutaneous ulcers in diabetic and immunodeficient mice, suggesting potential effectiveness for refractory skin wounds.
This study found that liquid nitrogen cryotherapy resulted in good responses in 33% of patients with recalcitrant alopecia areata, although nearly 30% showed no response.
March 2025 in “Pain Physician” This retrospective study found that applying local skin precooling before scalp nerve block significantly reduced injection site pain during PRP mesotherapy for patients with androgenetic alopecia, compared to those who did not receive precooling, thus improving patient comfort and compliance.
February 2021 in “Dermatological reviews” In this study, a specially adapted nonablative radiofrequency device significantly increased hair growth measures in most patients with androgenetic alopecia, including hair count and density.
March 2026 in “Materials Today Bio” This study developed a minimally invasive cryo-microneedles array patch (cryo-MAP) technique for transplanting hair follicle organoids, showing successful hair growth and complex skin structure regeneration with over 86% success in 15 days, opening new possibilities in tissue engineering.
January 2025 in “Advances in Clinical Medicine” This source highlights that fractional CO2 laser, as a minimally invasive technology, shows significant benefits in treating various skin and mucosal conditions by improving therapeutic outcomes, shortening recovery times, and enhancing precise personalized interventions through emerging technologies like AI and biomarker monitoring.
January 2019 in “Clinical Dermatology Open Access Journal” This report describes two cases of extensive alopecia areata successfully treated with a combination of intralesional corticosteroids and fractionated laser, suggesting the potential of laser treatment to promote hair regrowth.
February 2026 in “Journal of Cosmetic Dermatology” In this study, researchers found that combining cryotherapy with triamcinolone injections is equally effective as triamcinolone alone for treating patchy alopecia areata on the scalp and face, with no significant difference in outcomes between the two methods.
17 citations
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June 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This paper provides an overview of scalp cooling as an effective and safe intervention for preventing chemotherapy-induced alopecia, addressing its impact on cancer patients and survivors.
3 citations
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January 2020 in “Acta Dermatovenerologica Alpina Pannonica et Adriatica” Cryotherapy is effective for ingrown toenails, especially in single cases, but has high recurrence in younger and bilateral cases.
9 citations
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November 2024 in “Journal of Wound Management Official journal of the European Wound Management Association” Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.
October 2024 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)” This study suggests that follicular unit viability during hair transplantation is best preserved at lower storage temperatures, specifically around 4 °C, and provides insights into optimal cooling practices to enhance transplant success.
4 citations
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January 2015 in “Dermatology” This study concluded that using an erbium:YAG laser for calvarium trepanation and granulation tissue induction is comparable to the rose head burr, offering a beneficial alternative method.
8 citations
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September 2015 in “Radiotherapy and oncology” This article discusses the potential for scalp cooling to prevent hair loss during radiotherapy, drawing from its efficacy in chemotherapy contexts, but it provides no new experimental results.
April 2003 in “Journal of Cutaneous Medicine and Surgery” Lasers are effective for some skin conditions but can cause side effects like scarring and pigment changes; careful selection is important, and botulinum toxin type A is successful in reducing sweat in palmar hyperhidrosis.
19 citations
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January 2023 in “ACS Omega” This study developed sodium alginate and epigallocatechin gallate cryogels cross-linked with ferric ions, showing that they have strong antibacterial properties and rapid hemostatic abilities, making them promising candidates for wound dressing applications.