Efficacy of Intralesional Triamcinolone Acetonide Combined With Cryotherapy Compared to Intralesional Triamcinolone Acetonide Alone in Treating Limited Patchy Alopecia Areata of the Scalp and Face: A Prospective, Randomized, Within-Subject Controlled Trial

    February 2026 in “ Journal of Cosmetic Dermatology ”
    Sama Heidari, Reza Omid, Hanie Babaie … Zeinab Aryanian
    Studysummary In this study, researchers found that combining cryotherapy with triamcinolone injections is equally effective as triamcinolone alone for treating patchy alopecia areata on the scalp and face, with no significant difference in outcomes between the two methods.
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    Research cited in this study 14

    1. Alopecia Areata: Pathogenesis, Diagnosis, And Therapies MedComm · 2025
    2. Alopecia Areata: Pathogenesis, Current Treatments, and Future Perspectives Journal of Education Health and Sport · 2025
    3. Comparative Analysis of Temperature-Controlled Cryotherapy Versus Intralesional Triamcinolone Acetonide Injection for Alopecia Areata: An Intrasubject Split-Lesion Pilot Study Journal of the European Academy of Dermatology and Venereology · 2024
    4. Intralesional Vitamin D3 Versus Intralesional Triamcinolone Acetonide in Patchy Alopecia Areata: A Comparative Clinical and Dermoscopic Study Journal of Cosmetic and Laser Therapy · 2024
    5. Cold Shock Therapy Promotes Hair Growth in Association with Upregulation of Cold-Inducible RNA-Binding Protein and Vascular Endothelial Growth Factor Journal of Dermatological Science · 2024
    6. A Comparative Study of Fractional CO2 Laser with Topical Triamcinolone Acetonide Versus Intralesional Triamcinolone Acetonide in the Treatment of Alopecia Areata Journal of Cutaneous and Aesthetic Surgery · 2024
    7. Comparison of Clinical Efficacy and Trichoscopic Changes in Scalp Alopecia Areata Following Treatment with Intralesional Triamcinolone Acetonide and Autologous Platelet-Rich Plasma Clinical dermatology review · 2023
    8. Superficial Cryotherapy Versus Intralesional Corticosteroid Injection in Alopecia Areata: A Comparative Clinical and Dermoscopic Study ˜The œEgyptian Journal of Hospital Medicine · 2022
    9. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    10. A Comparative Study of Therapeutic Response to Intralesional Injections of Platelet-Rich Plasma Versus Triamcinolone Acetonide in Alopecia Areata Indian Dermatology Online Journal · 2020
    11. Efficacy of Different Concentrations of Intralesional Triamcinolone Acetonide for Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2019
    12. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    13. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    14. Benefit of Different Concentrations of Intralesional Triamcinolone Acetonide in Alopecia Areata: An Intrasubject Pilot Study Journal of the American Academy of Dermatology · 2015